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pubmed-article:17700253pubmed:abstractTextA recent analysis indicates that the excess odds ratio for lung cancer by smoking is described by a function that is linear in pack-years and exponential in the logarithm of smoking intensity and its square (Cancer Epidemiol Biomarkers Prev. 2006;15:517-523). The model suggests that below 15-20 cigarettes per day there is a "direct exposure rate" effect, ie, the excess odds ratio per pack-year for higher intensity (and shorter duration) smokers is greater than for lower-intensity (and longer duration) smokers. Above 20 cigarettes per day, there is an "inverse-exposure-rate" effect, ie, the excess odds ratio per pack-year for higher intensity smokers is smaller than for lower-intensity smokers.lld:pubmed
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pubmed-article:17700253pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:17700253pubmed:articleTitleCigarette smoking and lung cancer: modeling effect modification of total exposure and intensity.lld:pubmed
pubmed-article:17700253pubmed:affiliationBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA. lubinj@mail.nih.govlld:pubmed
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