Linked Life Data

17699604

Source:http://linkedlifedata.com/resource/pubmed/id/17699604

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2007-8-27
pubmed:abstractText
The specification of a subset of epiblast cells to acquire a neural fate constitutes the first step in the generation of the nervous system. Little is known about the signals required for neural induction in the mouse. We have analysed the role of BMP signalling in this process. We demonstrate that prior to gastrulation, Bmp2/4 signalling via Bmpr1a maintains epiblast pluripotency and prevents precocious neural differentiation of this tissue, at least in part by maintaining Nodal signalling. We find that during gastrulation, BMPs of the 60A subgroup cooperate with Bmp2/4 to maintain pluripotency. The inhibition of neural fate by BMPs is independent of FGF signalling, as inhibition of FGF signalling between 5.5 and 7.5 days post-coitum does not block neural differentiation in the mouse embryo. Together, our results demonstrate that inhibition of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not act as neural inducers in the post-implantation mouse embryo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3359-69
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17699604-Animals, pubmed-meshheading:17699604-Bone Morphogenetic Protein 2, pubmed-meshheading:17699604-Bone Morphogenetic Protein 4, pubmed-meshheading:17699604-Bone Morphogenetic Protein 7, pubmed-meshheading:17699604-Bone Morphogenetic Protein Receptors, Type I, pubmed-meshheading:17699604-Bone Morphogenetic Proteins, pubmed-meshheading:17699604-Cell Differentiation, pubmed-meshheading:17699604-Embryo, Mammalian, pubmed-meshheading:17699604-Embryonic Development, pubmed-meshheading:17699604-Fibroblast Growth Factors, pubmed-meshheading:17699604-Mice, pubmed-meshheading:17699604-Mice, Mutant Strains, pubmed-meshheading:17699604-Nervous System, pubmed-meshheading:17699604-Pluripotent Stem Cells, pubmed-meshheading:17699604-Signal Transduction, pubmed-meshheading:17699604-Transforming Growth Factor beta
pubmed:year
2007
pubmed:articleTitle
BMP signalling inhibits premature neural differentiation in the mouse embryo.
pubmed:affiliation
Molecular Embryology Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural