Source:http://linkedlifedata.com/resource/pubmed/id/17698944
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2007-8-16
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| pubmed:abstractText |
We have investigated the effect of subchronic administration of methidathion (MD) on ovary evaluated ameliorating effects of vitamins E and C against MD toxicity. Experimental groups were as follows: control group; a group treated with 5 mg/kg body weight MD (MD group); and a group treated with 5 mg/kg body weight MD plus vitamin E and vitamin C (MD + Vit group). MD and MD + Vit groups were given MD by gavage five days a week for four weeks at a dose level of 5 mg/kg/day by using corn oil as the vehicle. Serum malondialdehyde (MDA: an indicator of lipid peroxidation) concentration, serum activity of cholinesterase (ChE), and ovary histopathology were studied. The level of MDA increased significantly in the MD group compared with the control (P < 0.005). Serum MDA decreased significantly in the MD + Vit group compared with the MD group (P < 0.05). The activities of ChE decreased significantly both in the MD and MD + Vit groups compared with the controls ( P < 0.05). However, the decrease in the MD + Vit groups was less than in the MD group; the ChE activity in the MD + Vit group was significantly higher compared with MD group (P < 0.05). Number of ovarian follicles were significantly lower in the MD group compared to the controls (P < 0.05). Number of atretic follicles were significantly higher in the MD group than in the controls (P < 0.05). Follicle counts in MD + Vit group showed that all types of ovarian follicles were significantly higher, and a significant decrease in the number of atretic follicles compared with the MD group (P < 0.05). In conclusion, subchronic MD administration caused an ovarian damage, in addition, LPO may be one of the molecular mechanisms involved in MD-induced toxicity. Treatment with vitamins E and C after the administration of MD reduced LPO and ovarian damage.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ascorbic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Cholinesterases,
http://linkedlifedata.com/resource/pubmed/chemical/Insecticides,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Organothiophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Tocopherols,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Tocopherol,
http://linkedlifedata.com/resource/pubmed/chemical/methidathion
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0960-3271
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
26
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
491-8
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:17698944-Administration, Oral,
pubmed-meshheading:17698944-Animals,
pubmed-meshheading:17698944-Ascorbic Acid,
pubmed-meshheading:17698944-Cholinesterases,
pubmed-meshheading:17698944-Corpus Luteum,
pubmed-meshheading:17698944-Drug Administration Schedule,
pubmed-meshheading:17698944-Drug Therapy, Combination,
pubmed-meshheading:17698944-Estrous Cycle,
pubmed-meshheading:17698944-Fatigue,
pubmed-meshheading:17698944-Female,
pubmed-meshheading:17698944-Injections, Intraperitoneal,
pubmed-meshheading:17698944-Insecticides,
pubmed-meshheading:17698944-Intubation, Gastrointestinal,
pubmed-meshheading:17698944-Malondialdehyde,
pubmed-meshheading:17698944-Organothiophosphorus Compounds,
pubmed-meshheading:17698944-Ovarian Diseases,
pubmed-meshheading:17698944-Ovarian Follicle,
pubmed-meshheading:17698944-Rats,
pubmed-meshheading:17698944-Rats, Wistar,
pubmed-meshheading:17698944-Tocopherols,
pubmed-meshheading:17698944-Vitamins,
pubmed-meshheading:17698944-Weight Gain,
pubmed-meshheading:17698944-Weight Loss,
pubmed-meshheading:17698944-alpha-Tocopherol
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| pubmed:year |
2007
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| pubmed:articleTitle |
Ovarian toxicity in rats caused by methidathion and ameliorating effect of vitamins E and C.
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| pubmed:affiliation |
Department of Obstetrics and Gynecology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey. mguney@med.sdu.edu.tr
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| pubmed:publicationType |
Journal Article
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