Linked Life Data

17698848

Source:http://linkedlifedata.com/resource/pubmed/id/17698848

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17698848rdf:typepubmed:Citationlld:pubmed
pubmed-article:17698848lifeskim:mentionsumls-concept:C0020737lld:lifeskim
pubmed-article:17698848lifeskim:mentionsumls-concept:C0596902lld:lifeskim
pubmed-article:17698848lifeskim:mentionsumls-concept:C1442792lld:lifeskim
pubmed-article:17698848lifeskim:mentionsumls-concept:C1999216lld:lifeskim
pubmed-article:17698848lifeskim:mentionsumls-concept:C1159719lld:lifeskim
pubmed-article:17698848lifeskim:mentionsumls-concept:C1551336lld:lifeskim
pubmed-article:17698848lifeskim:mentionsumls-concept:C2003913lld:lifeskim
pubmed-article:17698848pubmed:issue40lld:pubmed
pubmed-article:17698848pubmed:dateCreated2007-10-1lld:pubmed
pubmed-article:17698848pubmed:abstractTextIbogaine, a hallucinogenic alkaloid with purported anti-addiction properties, inhibited serotonin transporter (SERT) noncompetitively by decreasing V(max) with little change in the K(m) for serotonin (5-HT). Ibogaine also inhibited binding to SERT of the cocaine analog 2beta-2-carbomethoxy-3-(4-[(125)I]iodophenyl)tropane. However, inhibition of binding was competitive, increasing the apparent K(D) without much change in B(max). Ibogaine increased the reactivity of cysteine residues positioned in the proposed cytoplasmic permeation pathway of SERT but not at nearby positions out of that pathway. In contrast, cysteines placed at positions in the extracellular permeation pathway reacted at slower rates in the presence of ibogaine. These results are consistent with the proposal that ibogaine binds to and stabilizes the state of SERT from which 5-HT dissociates to the cytoplasm, in contrast with cocaine, which stabilizes the state that binds extracellular 5-HT.lld:pubmed
pubmed-article:17698848pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17698848pubmed:languageenglld:pubmed
pubmed-article:17698848pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17698848pubmed:citationSubsetIMlld:pubmed
pubmed-article:17698848pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17698848pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17698848pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17698848pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17698848pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17698848pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17698848pubmed:statusMEDLINElld:pubmed
pubmed-article:17698848pubmed:monthOctlld:pubmed
pubmed-article:17698848pubmed:issn0021-9258lld:pubmed
pubmed-article:17698848pubmed:authorpubmed-author:RudnickGaryGlld:pubmed
pubmed-article:17698848pubmed:authorpubmed-author:ZhangYuan-Wei...lld:pubmed
pubmed-article:17698848pubmed:authorpubmed-author:CampbellScott...lld:pubmed
pubmed-article:17698848pubmed:authorpubmed-author:JacobsMiriam...lld:pubmed
pubmed-article:17698848pubmed:issnTypePrintlld:pubmed
pubmed-article:17698848pubmed:day5lld:pubmed
pubmed-article:17698848pubmed:volume282lld:pubmed
pubmed-article:17698848pubmed:ownerNLMlld:pubmed
pubmed-article:17698848pubmed:authorsCompleteYlld:pubmed
pubmed-article:17698848pubmed:pagination29441-7lld:pubmed
pubmed-article:17698848pubmed:dateRevised2007-12-3lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:meshHeadingpubmed-meshheading:17698848...lld:pubmed
pubmed-article:17698848pubmed:year2007lld:pubmed
pubmed-article:17698848pubmed:articleTitleIbogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.lld:pubmed
pubmed-article:17698848pubmed:affiliationDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, USA.lld:pubmed
pubmed-article:17698848pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17698848pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
http://linkedlifedata.com/r...http://linkedlifedata.com/r...pubmed-article:17698848lld:chembl
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17698848lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17698848lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17698848lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17698848lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17698848lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17698848lld:pubmed