|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
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pubmed:dateCreated |
2007-8-20
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|
pubmed:abstractText |
The in vitro activity of the lipopeptide PAL-Lys-Lys-NH(2) (PAL), alone or combined with either fluconazole (FLU) or amphotericin B (AMB), was investigated against 14 Cryptococcus neoformans isolates. PAL MICs ranged from 1.0 to 4.0 microg/ml. Fungicidal activity was observed. Synergy, defined as a fractional inhibitory concentration (FIC) index of < or =0.5, was observed in 21.4% of PAL/AMB interactions. Antagonism (FIC index>4) was never observed. The broad antifungal activity and the positive interactions with AMB suggest that PAL can represent a promising candidate in infections due to C. neoformans.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0196-9781
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
28
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1509-13
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|
pubmed:meshHeading |
|
|
pubmed:year |
2007
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|
pubmed:articleTitle |
In vitro activity of the synthetic lipopeptide PAL-Lys-Lys-NH(2) alone and in combination with antifungal agents against clinical isolates of Cryptococcus neoformans.
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|
pubmed:affiliation |
Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy.
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|
pubmed:publicationType |
Journal Article,
In Vitro
|
