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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-8-30
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pubmed:abstractText |
Interactions of killer cell immunoglobulin-like receptors (KIRs) with major histocompatibility complex (MHC) class I ligands diversify natural killer cell responses to infection. By analyzing sequence variation in diverse human populations, we show that the KIR3DL1/S1 locus encodes two lineages of polymorphic inhibitory KIR3DL1 allotypes that recognize Bw4 epitopes of protein">HLA-A and HLA-B and one lineage of conserved activating KIR3DS1 allotypes, also implicated in Bw4 recognition. Balancing selection has maintained these three lineages for over 3 million years. Variation was selected at D1 and D2 domain residues that contact HLA class I and at two sites on D0, the domain that enhances the binding of KIR3D to HLA class I. HLA-B variants that gained Bw4 through interallelic microconversion are also products of selection. A worldwide comparison uncovers unusual KIR3DL1/S1 evolution in modern sub-Saharan Africans. Balancing selection is weak and confined to D0, KIR3DS1 is rare and KIR3DL1 allotypes with similar binding sites predominate. Natural killer cells express the dominant KIR3DL1 at a high frequency and with high surface density, providing strong responses to cells perturbed in Bw4 expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1061-4036
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pubmed:author |
pubmed-author:Abi-RachedLaurentL,
pubmed-author:BrunoDanD,
pubmed-author:CarringtonChristine V FCV,
pubmed-author:ChandanayingyongDasdayaneeD,
pubmed-author:ChangYih-HsinYH,
pubmed-author:CrespíCatalinaC,
pubmed-author:DavisRonald WRW,
pubmed-author:FraserPatricia APA,
pubmed-author:GendzekhadzeKetevanK,
pubmed-author:GleimerMichaelM,
pubmed-author:HameedKamranK,
pubmed-author:KamkamidzeGiorgiG,
pubmed-author:KoramKwadwo AKA,
pubmed-author:KorbelDanielD,
pubmed-author:LayrisseZulayZ,
pubmed-author:MatamorosNuriaN,
pubmed-author:MilàJoanJ,
pubmed-author:NormanPaul JPJ,
pubmed-author:ParhamPeterP,
pubmed-author:ParkMyoung HeeMH,
pubmed-author:PitchappanRamasamy MRM,
pubmed-author:RamdathD DanDD,
pubmed-author:RileyEleanor MEM,
pubmed-author:RonaghiMostafaM,
pubmed-author:RowleyDonD,
pubmed-author:Saruhan-DireskeneliGüherG,
pubmed-author:ShiauMing-YuhMY,
pubmed-author:StephensHenry A FHA,
pubmed-author:StruikSiskeS,
pubmed-author:TyanDollyD,
pubmed-author:VaughanRobert WRW,
pubmed-author:VerityDavid HDH
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1092-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17694054-African Continental Ancestry Group,
pubmed-meshheading:17694054-Alleles,
pubmed-meshheading:17694054-Amino Acid Sequence,
pubmed-meshheading:17694054-Binding Sites,
pubmed-meshheading:17694054-Gene Frequency,
pubmed-meshheading:17694054-Genetics, Population,
pubmed-meshheading:17694054-HLA-B Antigens,
pubmed-meshheading:17694054-Humans,
pubmed-meshheading:17694054-Linkage Disequilibrium,
pubmed-meshheading:17694054-Molecular Sequence Data,
pubmed-meshheading:17694054-Phylogeny,
pubmed-meshheading:17694054-Polymorphism, Genetic,
pubmed-meshheading:17694054-Protein Structure, Tertiary,
pubmed-meshheading:17694054-Receptors, KIR3DL1,
pubmed-meshheading:17694054-Receptors, KIR3DS1,
pubmed-meshheading:17694054-Selection, Genetic,
pubmed-meshheading:17694054-Sequence Homology, Amino Acid
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pubmed:year |
2007
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pubmed:articleTitle |
Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans.
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pubmed:affiliation |
Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA. paul.norman@stanford.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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