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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-9-28
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pubmed:abstractText |
beta-Cell response to glucose is characterized by mitochondrial membrane potential (Delta Psi) hyperpolarization and the production of metabolites that serve as insulin secretory signals. We have previously shown that glucose-induced mitochondrial hyperpolarization accompanies the concentration-dependent increase in insulin secretion within a wide range of glucose concentrations. This observation represents the integrated response of a large number of mitochondria within each individual cell. However, it is currently unclear whether all mitochondria within a single beta-cell represent a metabolically homogenous population and whether fuel or other stimuli can recruit or silence sizable subpopulations of mitochondria. This study offers insight into the different metabolic states of beta-cell mitochondria.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:CollinsSheilaS,
pubmed-author:CorkeyBarbara EBE,
pubmed-author:DanialNika NNN,
pubmed-author:GrafSolomon ASA,
pubmed-author:HeartEmmaE,
pubmed-author:KatzmanShana MSM,
pubmed-author:MohamedHiboH,
pubmed-author:MolinaAnthony J AAJ,
pubmed-author:ShirihaiOrian SOS,
pubmed-author:TwigGiladG,
pubmed-author:WikstromJakob DJD,
pubmed-author:de VargasLina MoitosoLM
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pubmed:issnType |
Electronic
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2569-78
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17686943-Animals,
pubmed-meshheading:17686943-Calcium,
pubmed-meshheading:17686943-Cell Culture Techniques,
pubmed-meshheading:17686943-Glucose,
pubmed-meshheading:17686943-Insulin,
pubmed-meshheading:17686943-Insulin-Secreting Cells,
pubmed-meshheading:17686943-Ion Channels,
pubmed-meshheading:17686943-Islets of Langerhans,
pubmed-meshheading:17686943-Magnesium,
pubmed-meshheading:17686943-Male,
pubmed-meshheading:17686943-Membrane Potentials,
pubmed-meshheading:17686943-Mice,
pubmed-meshheading:17686943-Mice, Inbred C57BL,
pubmed-meshheading:17686943-Mice, Knockout,
pubmed-meshheading:17686943-Microscopy, Confocal,
pubmed-meshheading:17686943-Mitochondrial Membranes,
pubmed-meshheading:17686943-Mitochondrial Proteins,
pubmed-meshheading:17686943-bcl-Associated Death Protein
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pubmed:year |
2007
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pubmed:articleTitle |
beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels.
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pubmed:affiliation |
Tufts University, Department of Pharmacology and Experimental Therapeutics, 136 Harrison Ave., Boston, MA 02111, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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