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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-11-1
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pubmed:abstractText |
The antisaccade task provides a powerful tool with which to investigate the cognitive and neural systems underlying goal-directed behaviour, particularly in situations when the correct behavioural response requires the suppression of a prepotent response. Antisaccade errors (failures to suppress reflexive prosaccades towards sudden-onset targets) are increased in patients with damage to the dorsolateral prefrontal cortex, and in patients with schizophrenia. Nicotine has been found to improve antisaccade performance in patients with schizophrenia and healthy controls. This performance enhancing effect may be due to direct effects on the cholinergic system, but there has been no test of this hypothesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
195
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-53
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pubmed:meshHeading |
pubmed-meshheading:17676402-Adult,
pubmed-meshheading:17676402-Analysis of Variance,
pubmed-meshheading:17676402-Attention,
pubmed-meshheading:17676402-Benzhydryl Compounds,
pubmed-meshheading:17676402-Central Nervous System Stimulants,
pubmed-meshheading:17676402-Double-Blind Method,
pubmed-meshheading:17676402-Humans,
pubmed-meshheading:17676402-Male,
pubmed-meshheading:17676402-Memory,
pubmed-meshheading:17676402-Nicotine,
pubmed-meshheading:17676402-Nicotinic Agonists,
pubmed-meshheading:17676402-Reaction Time,
pubmed-meshheading:17676402-Saccades,
pubmed-meshheading:17676402-Task Performance and Analysis
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pubmed:year |
2007
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pubmed:articleTitle |
Non-cholinergic modulation of antisaccade performance: a modafinil-nicotine comparison.
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pubmed:affiliation |
Department of Psychology, Sussex University, Pevensey 1, Brighton, East Sussex, BN1 9QH, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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