|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
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pubmed:dateCreated |
1992-2-19
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|
pubmed:abstractText |
This report concerns the effect of bacterial endotoxin [lipopolysaccharide(LPS) and lipid A] on cultured human fetal astrocytes. Exposure to 1 micrograms/ml LPS or lipid A caused a striking stimulation of the rate of proliferation of the cells. The effect was most pronounced with exponentially growing cultures. Stimulation was associated with enhance DNA synthesis as ascertained by [3H]thymidine incorporation. These findings at the cellular level may be of relevance in the elucidation of the effects of bacterial endotoxins on the developing human brain.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0001-6322
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
82
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
384-8
|
|
pubmed:dateRevised |
2007-11-9
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|
pubmed:meshHeading |
pubmed-meshheading:1767632-Astrocytes,
pubmed-meshheading:1767632-Autoradiography,
pubmed-meshheading:1767632-Cell Division,
pubmed-meshheading:1767632-Cells, Cultured,
pubmed-meshheading:1767632-DNA,
pubmed-meshheading:1767632-Escherichia coli,
pubmed-meshheading:1767632-Fetus,
pubmed-meshheading:1767632-Frontal Lobe,
pubmed-meshheading:1767632-Humans,
pubmed-meshheading:1767632-Immunohistochemistry,
pubmed-meshheading:1767632-Lipid A,
pubmed-meshheading:1767632-Lipopolysaccharides,
pubmed-meshheading:1767632-Optic Chiasm,
pubmed-meshheading:1767632-Salmonella typhimurium,
pubmed-meshheading:1767632-Thymidine
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|
pubmed:year |
1991
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|
pubmed:articleTitle |
Stimulation of human fetal astrocyte proliferation by bacterial lipopolysaccharides and lipid A.
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|
pubmed:affiliation |
Division of Child Neurology, Tottori University School of Medicine, Yonago, Japan.
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pubmed:publicationType |
Journal Article
|
