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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-31
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pubmed:abstractText |
Airway obstruction in acute asthma is the result of airway smooth muscle contraction, inflammation and mucus plugging. Case reports suggest that mucolytic therapy might be beneficial in acute asthma. The aim of this study was to determine the efficacy of the mucolytic drug recombinant human deoxyribonuclease (rhDNase) in addition to standard treatment at the emergency department in children with an asthma exacerbation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1468-3296
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pubmed:author |
pubmed-author:BoogaardRR,
pubmed-author:FeithS W WSW,
pubmed-author:HekkelaanMM,
pubmed-author:HendriksTT,
pubmed-author:HopW C JWC,
pubmed-author:KouwenbergJ MJM,
pubmed-author:MerkusP J F MPJ,
pubmed-author:SchornagelRR,
pubmed-author:SmitFF,
pubmed-author:Vaessen-VerberneA A P HAA,
pubmed-author:de JongsteJ CJC
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pubmed:issnType |
Electronic
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
141-6
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pubmed:meshHeading |
pubmed-meshheading:17675321-Acute Disease,
pubmed-meshheading:17675321-Administration, Inhalation,
pubmed-meshheading:17675321-Adolescent,
pubmed-meshheading:17675321-Analysis of Variance,
pubmed-meshheading:17675321-Anti-Asthmatic Agents,
pubmed-meshheading:17675321-Asthma,
pubmed-meshheading:17675321-Child,
pubmed-meshheading:17675321-Child, Preschool,
pubmed-meshheading:17675321-Deoxyribonucleases,
pubmed-meshheading:17675321-Double-Blind Method,
pubmed-meshheading:17675321-Drug Therapy, Combination,
pubmed-meshheading:17675321-Female,
pubmed-meshheading:17675321-Hospitalization,
pubmed-meshheading:17675321-Humans,
pubmed-meshheading:17675321-Male,
pubmed-meshheading:17675321-Nebulizers and Vaporizers,
pubmed-meshheading:17675321-Recombinant Proteins,
pubmed-meshheading:17675321-Severity of Illness Index,
pubmed-meshheading:17675321-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Recombinant human deoxyribonuclease for the treatment of acute asthma in children.
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pubmed:affiliation |
Department of Pediatric Pulmonology, Erasmus MC-Sophia Children's Hospital, Rotterdam, P O Box 2060, 3000 CB Rotterdam, The Netherlands. r.boogaard@erasmusmc.nl
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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