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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-8-28
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pubmed:abstractText |
Modification of antigens represents a trigger for the generation of autoantibodies. In the pathogenesis of rheumatoid arthritis (RA), citrullination of proteins has been shown to be a critical process, and the determination of antibodies against citrullinated antigens has been a diagnostic milestone. We undertook this study to determine whether antibodies to mutated and citrullinated vimentin (MCV) could serve as a diagnostic and prognostic marker for RA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2503-11
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pubmed:meshHeading |
pubmed-meshheading:17665451-Arthritis, Rheumatoid,
pubmed-meshheading:17665451-Autoantibodies,
pubmed-meshheading:17665451-Autoantigens,
pubmed-meshheading:17665451-Biological Markers,
pubmed-meshheading:17665451-Cell Line,
pubmed-meshheading:17665451-Citrulline,
pubmed-meshheading:17665451-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17665451-Female,
pubmed-meshheading:17665451-Fibroblasts,
pubmed-meshheading:17665451-Humans,
pubmed-meshheading:17665451-Hydrogen Peroxide,
pubmed-meshheading:17665451-Male,
pubmed-meshheading:17665451-Middle Aged,
pubmed-meshheading:17665451-Mutation,
pubmed-meshheading:17665451-Oxidative Stress,
pubmed-meshheading:17665451-Protein Isoforms,
pubmed-meshheading:17665451-Recombinant Proteins,
pubmed-meshheading:17665451-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:17665451-Synovial Fluid,
pubmed-meshheading:17665451-Tandem Mass Spectrometry,
pubmed-meshheading:17665451-Vimentin
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pubmed:year |
2007
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pubmed:articleTitle |
Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis.
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pubmed:affiliation |
Orgentec Diagnostika, Mainz, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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