|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0080129,
umls-concept:C0376571,
umls-concept:C0449258,
umls-concept:C0920283,
umls-concept:C1412729,
umls-concept:C1426958,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1879547
|
|
pubmed:issue |
19
|
|
pubmed:dateCreated |
2007-9-17
|
|
pubmed:abstractText |
BACH1 (also known as FANCJ and BRIP1) is a DNA helicase that directly interacts with the C-terminal BRCT repeat of the breast cancer susceptibility protein BRCA1. Previous biochemical and functional analyses have suggested a role for the BACH1 homolog in Caenorhabditis elegans during DNA replication. Here, we report the association of BACH1 with a distinct BRCA1/BRCA2-containing complex during the S phase of the cell cycle. Depletion of BACH1 or BRCA1 using small interfering RNAs results in delayed entry into the S phase of the cell cycle. Such timely progression through S phase requires the helicase activity of BACH1. Importantly, cells expressing a dominant negative mutation in BACH1 that results in a defective helicase displayed increased activation of DNA damage checkpoints and genomic instability. BACH1 helicase is silenced during the G(1) phase of the cell cycle and is activated through a dephosphorylation event as cells enter S phase. These results point to a critical role for BACH1 helicase activity not only in the timely progression through the S phase but also in maintaining genomic stability.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-10426999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-1054854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-10549283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-10550006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-10635334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-10748114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-11046155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-11134068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-11207365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-11301010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-11329055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-11358863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-11573086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-11595410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-11889123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-12101400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-12383764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-12612652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-12878854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-1327851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-14534301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-14576433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-14578343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-14636569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-14681210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-14729053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-15020404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-16024119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-16116421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-16116424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-17525341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-2110504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-2184031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-7481765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-7545954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-7939630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-8589730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-9000507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-9034168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-9207057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-9267023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17664283-9811734
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BACH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BARD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BRCA1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/BRCA2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Basic-Leucine Zipper Transcription...,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/Fanconi Anemia Complementation...,
http://linkedlifedata.com/resource/pubmed/chemical/Multiprotein Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0270-7306
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6733-41
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17664283-Animals,
pubmed-meshheading:17664283-BRCA1 Protein,
pubmed-meshheading:17664283-BRCA2 Protein,
pubmed-meshheading:17664283-Basic-Leucine Zipper Transcription Factors,
pubmed-meshheading:17664283-Caenorhabditis elegans,
pubmed-meshheading:17664283-Chromatin,
pubmed-meshheading:17664283-DNA Damage,
pubmed-meshheading:17664283-Enzyme Activation,
pubmed-meshheading:17664283-Fanconi Anemia Complementation Group Proteins,
pubmed-meshheading:17664283-Humans,
pubmed-meshheading:17664283-Multiprotein Complexes,
pubmed-meshheading:17664283-RNA, Small Interfering,
pubmed-meshheading:17664283-S Phase,
pubmed-meshheading:17664283-Tumor Suppressor Proteins,
pubmed-meshheading:17664283-Ubiquitin-Protein Ligases
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase.
|
