Linked Life Data

17659873

Source:http://linkedlifedata.com/resource/pubmed/id/17659873

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2007-8-22
pubmed:abstractText
Novel macrolide antibiotics which contain a methylene unit between two nitrogen atoms of carbamate groups or between two nitrogen atoms of one carbamate and one urea group were synthesized using the Curtius rearrangement. Such linkers were shown to be stable under physiological conditions, and the resulting ketolides show potent in vitro and in vivo activity against macrolide-resistant respiratory pathogens. The SAR of various heterocycles and linkers was established.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5049-53
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Novel tethers in ketolide antibiotics.
pubmed:affiliation
Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. takushikaneko@gmail.com
pubmed:publicationType
Journal Article