Source:http://linkedlifedata.com/resource/pubmed/id/17654070
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2007-7-26
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pubmed:abstractText |
The present study aimed at differentiating rare types of heterozygous beta-thalassemia (thal) with normal Hb A(2) values from alpha-thal in Iranian carriers by globin chain synthesis in addition to other hematological parameters. Our study groups consisted of 51 normal subjects, 24 heterozygous beta- thalassemic subjects with high Hb A(2), 62 alpha-thal-2 subjects, 34 alpha-thal-1 subjects, six Hb H disease thalassemic subjects, 14 silent beta-thal subjects with normal Hb A(2) values, five deltabeta-thal subjects and two subjects with an association of alpha- and deltabeta-thal (total = 198). Analysis of globin chains was performed by high performance liquid chromatography (HPLC). The results showed that the alpha/beta ratio averages were close to the ones in the published literature, but with a greater standard deviation and a wider range. Globin chain synthesis (GCS) could be valuable in differentiating between microcytosis produced by silent beta-thal (heterozygous beta-thal with a normal Hb A(2) level) and that caused by alpha-thal. Since the complex genotype/phenotype relationship can lead to diagnostic difficulties, GCS cannot be used as the only diagnostic tool for thalassemia carrier detection. Therefore, a combination of different tests for each patient is required.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0363-0269
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pubmed:author |
pubmed-author:AkbariMohammad TaghiMT,
pubmed-author:AmirkhaniArefA,
pubmed-author:ArdjmandMohammadM,
pubmed-author:BayatParastooP,
pubmed-author:DehbonehSoghra RouhiSR,
pubmed-author:KhatamiShohrehS,
pubmed-author:MirzazadehRoghiehR,
pubmed-author:NajmabadiHosseinH,
pubmed-author:SadeghiSedighehS,
pubmed-author:SaeediParinazP,
pubmed-author:ZeinaliSirousS
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
333-41
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pubmed:meshHeading |
pubmed-meshheading:17654070-Case-Control Studies,
pubmed-meshheading:17654070-Chromatography, High Pressure Liquid,
pubmed-meshheading:17654070-Diagnosis, Differential,
pubmed-meshheading:17654070-Globins,
pubmed-meshheading:17654070-Heterozygote,
pubmed-meshheading:17654070-Humans,
pubmed-meshheading:17654070-Iran,
pubmed-meshheading:17654070-Thalassemia
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pubmed:year |
2007
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pubmed:articleTitle |
Globin chain synthesis is a useful complementary tool in the differential diagnosis of thalassemias.
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pubmed:affiliation |
Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran. sh-khatami@pasteur.ac.ir
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pubmed:publicationType |
Journal Article
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