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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-7-26
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pubmed:abstractText |
To clarify whether the activation of double-stranded RNA-dependent protein kinase (PKR) participates in the cell death induced by endoplasmic reticulum (ER) stress, the authors used cultured retinal ganglion cells (RGC-5, a rat ganglion cell line transformed with the E1A virus) in vitro and the effect of a PKR inhibitor (an imidazolo-oxindole derivative) on N-methyl-D-aspartate (NMDA)-induced retinal damage in mice in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hspa5 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Molecular Chaperones,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor CHOP,
http://linkedlifedata.com/resource/pubmed/chemical/Tunicamycin,
http://linkedlifedata.com/resource/pubmed/chemical/eIF-2 Kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3729-36
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17652745-Animals,
pubmed-meshheading:17652745-Animals, Outbred Strains,
pubmed-meshheading:17652745-Antiviral Agents,
pubmed-meshheading:17652745-Apoptosis,
pubmed-meshheading:17652745-Cell Line, Transformed,
pubmed-meshheading:17652745-Endoplasmic Reticulum,
pubmed-meshheading:17652745-Excitatory Amino Acid Agonists,
pubmed-meshheading:17652745-Heat-Shock Proteins,
pubmed-meshheading:17652745-Mice,
pubmed-meshheading:17652745-Molecular Chaperones,
pubmed-meshheading:17652745-N-Methylaspartate,
pubmed-meshheading:17652745-Phosphorylation,
pubmed-meshheading:17652745-RNA, Small Interfering,
pubmed-meshheading:17652745-Rats,
pubmed-meshheading:17652745-Retinal Ganglion Cells,
pubmed-meshheading:17652745-Transcription Factor CHOP,
pubmed-meshheading:17652745-Tunicamycin,
pubmed-meshheading:17652745-eIF-2 Kinase
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pubmed:year |
2007
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pubmed:articleTitle |
Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage.
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pubmed:affiliation |
Department of Biofunctional Molecules, Gifu Pharmaceutical University, Gifu, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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