| pubmed-article:17651527 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17651527 | lifeskim:mentions | umls-concept:C0330482 | lld:lifeskim |
| pubmed-article:17651527 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:17651527 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:17651527 | lifeskim:mentions | umls-concept:C0001527 | lld:lifeskim |
| pubmed-article:17651527 | lifeskim:mentions | umls-concept:C0206131 | lld:lifeskim |
| pubmed-article:17651527 | lifeskim:mentions | umls-concept:C0020564 | lld:lifeskim |
| pubmed-article:17651527 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17651527 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17651527 | lifeskim:mentions | umls-concept:C1509189 | lld:lifeskim |
| pubmed-article:17651527 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17651527 | pubmed:dateCreated | 2008-1-10 | lld:pubmed |
| pubmed-article:17651527 | pubmed:abstractText | Bitter melon (Momordica charantia; BM) has been shown to ameliorate diet-induced obesity and insulin resistance. To examine the effect of BM supplementation on cell size and lipid metabolism in adipose tissues, three groups of rats were respectively fed a high-fat diet supplemented without (HF group) or with 5 % lyophilised BM powder (HFB group), or with 0.01 % thiazolidinedione (TZD) (HFT group). A group of rats fed a low-fat diet was also included as a normal control. Hyperinsulinaemia and glucose intolerance were observed in the HF group but not in HFT and HFB groups. Although the number of large adipocytes (>180 microm) of both the HFB and HFT groups was significantly lower than that of the HF group, the adipose tissue mass, TAG content and glycerol-3-phosphate dehydrogenase activity of the HFB group were significantly lower than those of the HFT group, implying that BM might reduce lipogenesis in adipose tissue. Experiment 2 was then conducted to examine the expression of lipogenic genes in adipose tissues of rats fed low-fat, HF or HFB diets. The HFB group showed significantly lower mRNA levels of fatty acid synthase, acetyl-CoA carboxylase-1, lipoprotein lipase and adipocyte fatty acid-binding protein than the HF group (P < 0.05). These results indicate BM can reduce insulin resistance as effective as the anti-diabetic drug TZD. Furthermore, BM can suppress the visceral fat accumulation and inhibit adipocyte hypertrophy, which may be associated with markedly down regulated expressions of lipogenic genes in the adipose. | lld:pubmed |
| pubmed-article:17651527 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17651527 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17651527 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17651527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17651527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17651527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17651527 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17651527 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17651527 | pubmed:issn | 0007-1145 | lld:pubmed |
| pubmed-article:17651527 | pubmed:author | pubmed-author:HuangHui-Ling... | lld:pubmed |
| pubmed-article:17651527 | pubmed:author | pubmed-author:ChaoPei-MinPM | lld:pubmed |
| pubmed-article:17651527 | pubmed:author | pubmed-author:HuangChing-Ja... | lld:pubmed |
| pubmed-article:17651527 | pubmed:author | pubmed-author:HongYa-WenYW | lld:pubmed |
| pubmed-article:17651527 | pubmed:author | pubmed-author:WongYou-HongY... | lld:pubmed |
| pubmed-article:17651527 | pubmed:author | pubmed-author:ChenYing-Nien... | lld:pubmed |
| pubmed-article:17651527 | pubmed:author | pubmed-author:ChyuanJong-Ho... | lld:pubmed |
| pubmed-article:17651527 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17651527 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:17651527 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17651527 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17651527 | pubmed:pagination | 230-9 | lld:pubmed |
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| pubmed-article:17651527 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17651527 | pubmed:articleTitle | Bitter melon (Momordica charantia L.) inhibits adipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats. | lld:pubmed |
| pubmed-article:17651527 | pubmed:affiliation | Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan. | lld:pubmed |
| pubmed-article:17651527 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17651527 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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