Source:http://linkedlifedata.com/resource/pubmed/id/17651527
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2008-1-10
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| pubmed:abstractText |
Bitter melon (Momordica charantia; BM) has been shown to ameliorate diet-induced obesity and insulin resistance. To examine the effect of BM supplementation on cell size and lipid metabolism in adipose tissues, three groups of rats were respectively fed a high-fat diet supplemented without (HF group) or with 5 % lyophilised BM powder (HFB group), or with 0.01 % thiazolidinedione (TZD) (HFT group). A group of rats fed a low-fat diet was also included as a normal control. Hyperinsulinaemia and glucose intolerance were observed in the HF group but not in HFT and HFB groups. Although the number of large adipocytes (>180 microm) of both the HFB and HFT groups was significantly lower than that of the HF group, the adipose tissue mass, TAG content and glycerol-3-phosphate dehydrogenase activity of the HFB group were significantly lower than those of the HFT group, implying that BM might reduce lipogenesis in adipose tissue. Experiment 2 was then conducted to examine the expression of lipogenic genes in adipose tissues of rats fed low-fat, HF or HFB diets. The HFB group showed significantly lower mRNA levels of fatty acid synthase, acetyl-CoA carboxylase-1, lipoprotein lipase and adipocyte fatty acid-binding protein than the HF group (P < 0.05). These results indicate BM can reduce insulin resistance as effective as the anti-diabetic drug TZD. Furthermore, BM can suppress the visceral fat accumulation and inhibit adipocyte hypertrophy, which may be associated with markedly down regulated expressions of lipogenic genes in the adipose.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
0007-1145
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
99
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
230-9
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| pubmed:meshHeading |
pubmed-meshheading:17651527-Adipocytes,
pubmed-meshheading:17651527-Adipose Tissue,
pubmed-meshheading:17651527-Animals,
pubmed-meshheading:17651527-Anti-Obesity Agents,
pubmed-meshheading:17651527-Cell Size,
pubmed-meshheading:17651527-Diet,
pubmed-meshheading:17651527-Dietary Fats,
pubmed-meshheading:17651527-Dietary Supplements,
pubmed-meshheading:17651527-Down-Regulation,
pubmed-meshheading:17651527-Eating,
pubmed-meshheading:17651527-Glucose Tolerance Test,
pubmed-meshheading:17651527-Hypertrophy,
pubmed-meshheading:17651527-Insulin Resistance,
pubmed-meshheading:17651527-Lipid Metabolism,
pubmed-meshheading:17651527-Lipogenesis,
pubmed-meshheading:17651527-Male,
pubmed-meshheading:17651527-Momordica charantia,
pubmed-meshheading:17651527-Obesity,
pubmed-meshheading:17651527-Organ Size,
pubmed-meshheading:17651527-Phytotherapy,
pubmed-meshheading:17651527-Plant Extracts,
pubmed-meshheading:17651527-Rats,
pubmed-meshheading:17651527-Rats, Wistar,
pubmed-meshheading:17651527-Weight Gain
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| pubmed:year |
2008
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| pubmed:articleTitle |
Bitter melon (Momordica charantia L.) inhibits adipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats.
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| pubmed:affiliation |
Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|