Linked Life Data

17644971

Source:http://linkedlifedata.com/resource/pubmed/id/17644971

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-7-24
pubmed:abstractText
Energy metabolism is a key factor supporting sperm function. Sustaining sperm motility and active protein modifications such as phosphorylation could be the reason why sperm require exceptionally more ATP than other cells. Many methods have been used to understand the relationship between energy metabolism and sperm function. These approaches have identified critical metabolic pathways that support specific processes during germ cell development and fertilisation. In round spermatids, lactate and pyruvate are the preferred substrates and the use of glucose is limited, however, during epididymal maturation sperm expand to use glycolysis. While the acrosome reaction requires lactate or pyruvate for ATP production by oxidative phosphorylation, gamete fusion requires glucose to produce NADPH by the pentose phosphate pathway. Sperm motility appears to be supported by relatively low ATP levels, but achievement of high ATP levels are essential for tyrosine phosphorylation linked to hyperactivation. Thus, each individual process and event requires a different substrate and metabolic pathway. Despite different preferences for energy substrates and metabolic pathways between species, analysis of knockout mice revealed that glycolysis is indispensable for mouse sperm function and that oxidative phosphorylation is not essential for male fertility. This suggests that glycolysis could compensate for the lack of oxidative phosphorylation and recover most sperm function. Spermatogenic cell-specific glycolytic enzymes may confer flexible use of substrates and adapt to unexpected conditions for substrates in the female reproductive tract.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
309-25
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Energy metabolism and sperm function.
pubmed:affiliation
Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599-7090, USA. miki@med.unc.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural