| pubmed-article:17637690 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17637690 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:17637690 | lifeskim:mentions | umls-concept:C0439859 | lld:lifeskim |
| pubmed-article:17637690 | lifeskim:mentions | umls-concept:C0242602 | lld:lifeskim |
| pubmed-article:17637690 | lifeskim:mentions | umls-concept:C1328050 | lld:lifeskim |
| pubmed-article:17637690 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17637690 | pubmed:dateCreated | 2007-9-5 | lld:pubmed |
| pubmed-article:17637690 | pubmed:abstractText | Peg-filgrastim is a form of G-CSF with a sustained duration of action due to self-limited clearance. We administered 6 mg peg-filgrastim to 18 autograft recipients on day +1 after transplantation for hematologic malignancies. Plasma samples were collected at baseline and during transplantation. Hematopoietic recovery and clinical outcomes were compared to the historical data of 54 patients not receiving G-CSF. Patients receiving peg-filgrastim achieved a serum level of 115 000 pg/ml on day +2, 24 h after drug administration. Drug level maintained a plateau until day +8 and, after day +10, declined concomitantly with myeloid recovery. Patients experienced prompt neutrophil recovery: days +9 and +10 to 500 and 1000 neutrophils per microliter, and 4 days with an absolute neutrophil count <100 cells per microliter. Duration of antibiotic therapy was significantly shortened, but we did not observe significant differences in other end points. In conclusion, peg-filgrastim was well tolerated and efficacious, and hastened myeloid recovery. | lld:pubmed |
| pubmed-article:17637690 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17637690 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637690 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17637690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17637690 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17637690 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17637690 | pubmed:issn | 0268-3369 | lld:pubmed |
| pubmed-article:17637690 | pubmed:author | pubmed-author:De MatteisSS | lld:pubmed |
| pubmed-article:17637690 | pubmed:author | pubmed-author:LeoneGG | lld:pubmed |
| pubmed-article:17637690 | pubmed:author | pubmed-author:SicaSS | lld:pubmed |
| pubmed-article:17637690 | pubmed:author | pubmed-author:De VitaSS | lld:pubmed |
| pubmed-article:17637690 | pubmed:author | pubmed-author:d'OnofrioGG | lld:pubmed |
| pubmed-article:17637690 | pubmed:author | pubmed-author:LaurentiLL | lld:pubmed |
| pubmed-article:17637690 | pubmed:author | pubmed-author:ChiusoloPP | lld:pubmed |
| pubmed-article:17637690 | pubmed:author | pubmed-author:PiccirilloNN | lld:pubmed |
| pubmed-article:17637690 | pubmed:author | pubmed-author:SoràFF | lld:pubmed |
| pubmed-article:17637690 | pubmed:author | pubmed-author:ReddicontoGG | lld:pubmed |
| pubmed-article:17637690 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17637690 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:17637690 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17637690 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17637690 | pubmed:pagination | 579-83 | lld:pubmed |
| pubmed-article:17637690 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:meshHeading | pubmed-meshheading:17637690... | lld:pubmed |
| pubmed-article:17637690 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17637690 | pubmed:articleTitle | Kinetics of peg-filgrastim after high-dose chemotherapy and autologous peripheral blood stem cell transplantation. | lld:pubmed |
| pubmed-article:17637690 | pubmed:affiliation | 1Haematology Institute, A Gemelli Hospital, Catholic University, Rome, Italy. n.piccirillo@rm.unicatt.it | lld:pubmed |
| pubmed-article:17637690 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17637690 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:17637690 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
