Source:http://linkedlifedata.com/resource/pubmed/id/17637690
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2007-9-5
|
| pubmed:abstractText |
Peg-filgrastim is a form of G-CSF with a sustained duration of action due to self-limited clearance. We administered 6 mg peg-filgrastim to 18 autograft recipients on day +1 after transplantation for hematologic malignancies. Plasma samples were collected at baseline and during transplantation. Hematopoietic recovery and clinical outcomes were compared to the historical data of 54 patients not receiving G-CSF. Patients receiving peg-filgrastim achieved a serum level of 115 000 pg/ml on day +2, 24 h after drug administration. Drug level maintained a plateau until day +8 and, after day +10, declined concomitantly with myeloid recovery. Patients experienced prompt neutrophil recovery: days +9 and +10 to 500 and 1000 neutrophils per microliter, and 4 days with an absolute neutrophil count <100 cells per microliter. Duration of antibiotic therapy was significantly shortened, but we did not observe significant differences in other end points. In conclusion, peg-filgrastim was well tolerated and efficacious, and hastened myeloid recovery.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0268-3369
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
579-83
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:17637690-Adolescent,
pubmed-meshheading:17637690-Adult,
pubmed-meshheading:17637690-Combined Modality Therapy,
pubmed-meshheading:17637690-Female,
pubmed-meshheading:17637690-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:17637690-Hodgkin Disease,
pubmed-meshheading:17637690-Humans,
pubmed-meshheading:17637690-Lymphocyte Count,
pubmed-meshheading:17637690-Lymphoma, Non-Hodgkin,
pubmed-meshheading:17637690-Male,
pubmed-meshheading:17637690-Middle Aged,
pubmed-meshheading:17637690-Neutrophils,
pubmed-meshheading:17637690-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:17637690-Platelet Count,
pubmed-meshheading:17637690-Polyethylene Glycols,
pubmed-meshheading:17637690-Recombinant Proteins,
pubmed-meshheading:17637690-Recovery of Function,
pubmed-meshheading:17637690-Transplantation, Autologous,
pubmed-meshheading:17637690-Treatment Outcome
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Kinetics of peg-filgrastim after high-dose chemotherapy and autologous peripheral blood stem cell transplantation.
|
| pubmed:affiliation |
1Haematology Institute, A Gemelli Hospital, Catholic University, Rome, Italy. n.piccirillo@rm.unicatt.it
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|