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pubmed-article:1763040pubmed:abstractTextTo investigate the evolution of the mammalian sex chromosomes, we have compared the gene content of the X chromosomes in the mammalian groups most distantly related to man (marsupials and monotremes). Previous work established that genes on the long arm of the human X chromosome are conserved on the X chromosomes in all mammals, revealing that this region was part of an ancient mammalian X chromosome. However, we now report that several genes located on the short arm of the human X chromosome are absent from the platypus X chromosome, as well as from the marsupial X chromosome. Because monotremes and marsupials diverged independently from eutherian mammals, this finding implies that the whole human X short arm region is a relatively recent addition to the X chromosome in eutherian mammals.lld:pubmed
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pubmed-article:1763040pubmed:articleTitleSex chromosome evolution: platypus gene mapping suggests that part of the human X chromosome was originally autosomal.lld:pubmed
pubmed-article:1763040pubmed:affiliationDepartment of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.lld:pubmed
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