Linked Life Data

17613323

Source:http://linkedlifedata.com/resource/pubmed/id/17613323

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-7-6
pubmed:abstractText
It is increasingly appreciated that the mechanical properties of the microenvironment around cells exerts a significant influence on cell behavior, but careful consideration of what is the physiologically relevant elasticity for specific cell types is required to produce results that meaningfully recapitulate in vivo development. Here we outline methodologies for excising and characterizing the effective microelasticity of tissues; but first we describe and validate an atomic force microscopy (AFM) method as applied to two comparatively simple hydrogel systems. With tissues and gels sufficiently understood, the latter can be appropriately tuned to mimic the desired tissue microenvironment for a given cell type. The approach is briefly illustrated with lineage commitment of stem cells due to matrix elasticity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0091-679X
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
521-45
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation.
pubmed:affiliation
Biophysical Engineering and Polymers Laboratory, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
pubmed:publicationType
Journal Article