Linked Life Data

17611219

Source:http://linkedlifedata.com/resource/pubmed/id/17611219

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2007-7-11
pubmed:abstractText
Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles during vascular development and physiology in vertebrates. These roles include regulation of artery/vein differentiation in endothelial and vascular smooth muscle cells, regulation of blood vessel sprouting and branching during both normal development and tumor angiogenesis, and the differentiation and physiological responses of vascular smooth muscle cells. Defects in Notch signaling also cause inherited vascular and cardiovascular diseases. In this review, I summarize recent findings and discuss the growing relevance of Notch pathway modulation for therapeutic applications in disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2709-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Notch signaling in vascular development and physiology.
pubmed:affiliation
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. tom.gridley@jax.org
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural