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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-8-16
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pubmed:abstractText |
Gemcitabine, a deoxycytidine nucleoside analog, is the current standard chemotherapy used as first-line treatment for patients with locally advanced or metastatic cancer of the pancreas, and extends life survival by 5.7 months. Advanced pancreatic cancer thus remains a highly unmet medical need and new therapeutic agents are required for this patient population. Troxacitabine (Troxatyl) is the first unnatural L-nucleoside analog to show potent preclinical antitumor activity and is currently under clinical investigation. Troxacitabine was recently evaluated as a first-line therapy in 54 patients with advanced adenocarcinoma of the pancreas and gave comparable overall results to those reported with gemcitabine in recently published randomized trials.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-10742981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-10778991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-10870114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-10906132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-10980945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-11157029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-11320667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-11355958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-11585758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-11741981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-12080078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-12451476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-12869554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-12955470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-15171046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-15668286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-16269377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-1732772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-1876783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-2078794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-6382953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-7559445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-7606719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-7837220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-7945430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-8620496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-8797590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-9172997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-9196156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-9354442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17608948-9699681
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17608948-Adenocarcinoma,
pubmed-meshheading:17608948-Animals,
pubmed-meshheading:17608948-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17608948-Cytosine,
pubmed-meshheading:17608948-Deoxycytidine,
pubmed-meshheading:17608948-Dioxolanes,
pubmed-meshheading:17608948-Drug Synergism,
pubmed-meshheading:17608948-Female,
pubmed-meshheading:17608948-Humans,
pubmed-meshheading:17608948-Mice,
pubmed-meshheading:17608948-Mice, Nude,
pubmed-meshheading:17608948-Mice, SCID,
pubmed-meshheading:17608948-Pancreatic Neoplasms,
pubmed-meshheading:17608948-Treatment Outcome,
pubmed-meshheading:17608948-Tritium,
pubmed-meshheading:17608948-Tumor Cells, Cultured,
pubmed-meshheading:17608948-Uridine,
pubmed-meshheading:17608948-Xenograft Model Antitumor Assays
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pubmed:year |
2007
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pubmed:articleTitle |
Synergistic activity of troxacitabine (Troxatyl) and gemcitabine in pancreatic cancer.
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pubmed:affiliation |
Department of Oncology, University of Alberta, and Cross Cancer Institute, Edmonton, Alberta, Canada. vijayada@cancerboard.ab.ca <vijayada@cancerboard.ab.ca>
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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