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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-2-11
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pubmed:abstractText |
A B cell lymphoma-associated chromosomal translocation, t(10;14)(q24;q32), juxtaposes the immunoglobulin C alpha 1 locus to a novel gene, lyt-10. The normal lyt-10 cDNA codes for a 98 kd protein which displays amino-terminal homology with the rel (DNA-binding) domain of the NF-kappa B-rel family of transcription factors and carboxy-terminal homology with the NF-kappa B p50 precursor protein, including the putative proteolytic cleavage domain (poly-G) and the ankyrin-like repeat domains. The lyt-10 protein can bind to kappa B sequences in vitro, although with different specificity from NF-kappa B p50, and in vitro DNA-binding is activated by removal of the ankyrin domain. Chromosomal translocation generates an lyt-10-C alpha 1 fusion gene coding for a protein that retains the rel effector domain, lacks the ankyrin regulatory domain, and binds kappa B sequences in vitro, suggesting its constitutive activation in vivo. Analogous rearrangements of the lyt-10 gene have been found in an additional three cases of lymphoid neoplasia. The lyt-10 gene defines a new subfamily (rel/poly-G/ankyrin) of NF-kappa B-rel transcription factors with potential for oncogenic activation in human cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
67
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pubmed:geneSymbol |
NFKB,
c-rel,
lyt-10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1075-87
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1760839-Amino Acid Sequence,
pubmed-meshheading:1760839-Base Sequence,
pubmed-meshheading:1760839-Chromosomes, Human, Pair 10,
pubmed-meshheading:1760839-Chromosomes, Human, Pair 14,
pubmed-meshheading:1760839-Cloning, Molecular,
pubmed-meshheading:1760839-DNA,
pubmed-meshheading:1760839-DNA-Binding Proteins,
pubmed-meshheading:1760839-Gene Expression,
pubmed-meshheading:1760839-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:1760839-Genes, Immunoglobulin,
pubmed-meshheading:1760839-Humans,
pubmed-meshheading:1760839-Immunoglobulin alpha-Chains,
pubmed-meshheading:1760839-Lymphoma, B-Cell,
pubmed-meshheading:1760839-Molecular Sequence Data,
pubmed-meshheading:1760839-Multigene Family,
pubmed-meshheading:1760839-NF-kappa B,
pubmed-meshheading:1760839-Oligodeoxyribonucleotides,
pubmed-meshheading:1760839-Oncogenes,
pubmed-meshheading:1760839-Polymerase Chain Reaction,
pubmed-meshheading:1760839-RNA, Messenger,
pubmed-meshheading:1760839-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1760839-Restriction Mapping,
pubmed-meshheading:1760839-Transcription Factors,
pubmed-meshheading:1760839-Translocation, Genetic
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pubmed:year |
1991
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pubmed:articleTitle |
B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50.
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pubmed:affiliation |
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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