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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2007-7-30
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pubmed:abstractText |
Second-generation carnosine analogs bearing the histidyl-hydrazide moiety have been synthesized and tested for their efficiency in scavenging malondialdehyde (MDA) derived from lipid peroxidation and for their ability to reverse the glycation process in the glucose-ethylamine Schiff base model. The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6158-63
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pubmed:meshHeading |
pubmed-meshheading:17604632-Ascorbic Acid,
pubmed-meshheading:17604632-Carnosine,
pubmed-meshheading:17604632-Glycosylation,
pubmed-meshheading:17604632-Histidine,
pubmed-meshheading:17604632-Hydrazines,
pubmed-meshheading:17604632-Iron,
pubmed-meshheading:17604632-Lipid Peroxidation,
pubmed-meshheading:17604632-Liposomes,
pubmed-meshheading:17604632-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17604632-Malondialdehyde,
pubmed-meshheading:17604632-Oxidative Stress,
pubmed-meshheading:17604632-Schiff Bases,
pubmed-meshheading:17604632-Thiobarbituric Acid Reactive Substances
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pubmed:year |
2007
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pubmed:articleTitle |
Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs.
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pubmed:affiliation |
Institute of Biomolecular Chemistry of CNR, Department of Chemical Sciences, University of Padua, Via F. Marzolo, 1-35131 Padova, Italy. andrea.guito@unipd.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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