Linked Life Data

17591944

Source:http://linkedlifedata.com/resource/pubmed/id/17591944

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-10-5
pubmed:abstractText
Galectins are emerging as a family of proteins that play an important role in several steps of tumorigenesis. Evidence is accumulating that galectins are expressed by the tumor endothelium, where they contribute to different steps of tumor progression such as immune escape and metastasis. Recent studies have identified an important role for galectins in tumor angiogenesis. Moreover, it has been shown that galectins in the endothelium can be targeted for therapeutic applications. This opens a window of opportunity for the development of tumor-type independent treatment strategies. This review focuses on the expression of galectins in the tumor endothelium, their contribution to tumor progression, and their application in tumor-type independent cancer therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2819-27
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Galectins in the tumor endothelium: opportunities for combined cancer therapy.
pubmed:affiliation
Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology, University Maastricht and Academic Hospital Maastricht, the Netherlands. aw.griffioen@path.unimaas.nl
pubmed:publicationType
Journal Article, Review