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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-6-26
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pubmed:abstractText |
PK11195 is a ligand with high affinity for peripheral benzodiazepine receptors (PBRs), which are present in large numbers in macrophages. PBRs play a role in antioxidant pathways and apoptosis, key factors in control of lung health. Intrapulmonary PBRs, assessed in vivo by positron emission tomography (PET), are decreased in interstitial lung disease (ILD) despite increased macrophage numbers. We wished to ascertain whether the observed decrease in in vivo expression of PBRs in the PET scans could be accounted for by a reduction in PBRs per cell by saturation-binding assays of R-PK11195 in cells obtained by bronchoalveolar lavage (BAL).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0969-8051
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
553-8
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pubmed:dateRevised |
2008-5-14
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pubmed:meshHeading |
pubmed-meshheading:17591555-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:17591555-Cells, Cultured,
pubmed-meshheading:17591555-Deuterium,
pubmed-meshheading:17591555-Extracellular Fluid,
pubmed-meshheading:17591555-Humans,
pubmed-meshheading:17591555-Isoquinolines,
pubmed-meshheading:17591555-Lung Diseases, Interstitial,
pubmed-meshheading:17591555-Radiopharmaceuticals,
pubmed-meshheading:17591555-Receptors, GABA
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pubmed:year |
2007
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pubmed:articleTitle |
Peripheral-type benzodiazepine receptors in bronchoalveolar lavage cells of patients with interstitial lung disease.
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pubmed:affiliation |
Imperial College London, Hammersmith Campus, London, UK. howard.branley@whittington.nhs.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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