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rdf:type |
|
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lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
2007-6-25
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pubmed:abstractText |
With respect to CD8 effector T cells, interleukin-12 (IL-12) and transforming growth factor beta (TGFbeta) are 2 cytokines that exert opposing effects. IL-12 promotes antitumor immune responses by augmenting activated CD8 T-cell proliferation and interferon-gamma secretion. Conversely, TGFbeta generates a permissive environment for cancer growth, in part by antagonizing the effects of immunomodulatory cytokines, including IL-12. We demonstrate that TGFbeta-resistant T cells are capable of sustaining IL-12-induced mitogenesis and interferon-gamma secretion in a TGFbeta-rich milieu. Furthermore, in 2 murine tumor models associated with high TGFbeta1 levels in the local microenvironment, treatment with IL-12 and adoptively transferred TGFbeta-resistant T cells provided improved survival times. These results suggest that combining IL-12 with TGFbeta neutralization strategies may be effective in enhancing antitumor immune responses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
1524-9557
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
479-89
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17589288-Animals,
pubmed-meshheading:17589288-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17589288-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17589288-Cell Line,
pubmed-meshheading:17589288-Cell Proliferation,
pubmed-meshheading:17589288-Female,
pubmed-meshheading:17589288-Immunotherapy, Adoptive,
pubmed-meshheading:17589288-Interferon-gamma,
pubmed-meshheading:17589288-Interleukin-12,
pubmed-meshheading:17589288-Male,
pubmed-meshheading:17589288-Melanoma, Experimental,
pubmed-meshheading:17589288-Mice,
pubmed-meshheading:17589288-Mice, Inbred C57BL,
pubmed-meshheading:17589288-Mice, Transgenic,
pubmed-meshheading:17589288-Neoplasms, Experimental,
pubmed-meshheading:17589288-Papilloma, Choroid Plexus,
pubmed-meshheading:17589288-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:17589288-T-Lymphocytes,
pubmed-meshheading:17589288-Transforming Growth Factor beta1
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pubmed:articleTitle |
Enhancing antitumor immunity: combining IL-12 with TGFbeta1 antagonism.
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pubmed:affiliation |
Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, Urbana, IL 61801, USA. tfan@cvm.uiuc.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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