pubmed-article:17585049 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17585049 | lifeskim:mentions | umls-concept:C1423021 | lld:lifeskim |
pubmed-article:17585049 | lifeskim:mentions | umls-concept:C2700298 | lld:lifeskim |
pubmed-article:17585049 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
pubmed-article:17585049 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
pubmed-article:17585049 | pubmed:issue | 8 | lld:pubmed |
pubmed-article:17585049 | pubmed:dateCreated | 2007-7-19 | lld:pubmed |
pubmed-article:17585049 | pubmed:abstractText | MicroRNAs have important functions during animal development and homeostasis through post-transcriptional regulation of their cognate mRNA targets. ZFHX1B is a transcriptional repressor involved in the TGFbeta signaling pathway and in processes of epithelial to mesenchymal transition via regulation of E-cadherin. We show that Zfhx1b and miR-200b are regionally coexpressed in the adult mouse brain and that miR-200b represses the expression of Zfhx1b via multiple sequence elements present in the 3'-untranslated region. Overexpression of miR-200b leads to repression of endogenous ZFHX1B, and inhibition of miR-200b relieves the repression of ZFHX1B. In accordance with these findings, miR-200b regulates the activity of the E-cadherin promoter. | lld:pubmed |
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pubmed-article:17585049 | pubmed:language | eng | lld:pubmed |
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pubmed-article:17585049 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:17585049 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17585049 | pubmed:month | Aug | lld:pubmed |
pubmed-article:17585049 | pubmed:issn | 1355-8382 | lld:pubmed |
pubmed-article:17585049 | pubmed:author | pubmed-author:LundAnders... | lld:pubmed |
pubmed-article:17585049 | pubmed:author | pubmed-author:KauppinenSaka... | lld:pubmed |
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pubmed-article:17585049 | pubmed:author | pubmed-author:Christofferse... | lld:pubmed |
pubmed-article:17585049 | pubmed:author | pubmed-author:OromUlf... | lld:pubmed |
pubmed-article:17585049 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17585049 | pubmed:volume | 13 | lld:pubmed |
pubmed-article:17585049 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17585049 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17585049 | pubmed:pagination | 1172-8 | lld:pubmed |
pubmed-article:17585049 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:17585049 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17585049 | pubmed:articleTitle | miR-200b mediates post-transcriptional repression of ZFHX1B. | lld:pubmed |
pubmed-article:17585049 | pubmed:affiliation | Biotech Research and Innovation Centre, Copenhagen, Denmark. | lld:pubmed |
pubmed-article:17585049 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17585049 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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