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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-7-19
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pubmed:abstractText |
MicroRNAs have important functions during animal development and homeostasis through post-transcriptional regulation of their cognate mRNA targets. ZFHX1B is a transcriptional repressor involved in the TGFbeta signaling pathway and in processes of epithelial to mesenchymal transition via regulation of E-cadherin. We show that Zfhx1b and miR-200b are regionally coexpressed in the adult mouse brain and that miR-200b represses the expression of Zfhx1b via multiple sequence elements present in the 3'-untranslated region. Overexpression of miR-200b leads to repression of endogenous ZFHX1B, and inhibition of miR-200b relieves the repression of ZFHX1B. In accordance with these findings, miR-200b regulates the activity of the E-cadherin promoter.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-10400677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-10487759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-10949939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-11279515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-11430829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-11448942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-11452083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-11592033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-11641272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-11726523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-11857784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-12414534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-12522767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-12743038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-14508493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-14623443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-14631048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-14681208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-14730017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-15006694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-15014042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-15026811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-15105502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-15372042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-15372072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-15525708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-15652477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-15742334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-15766526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16081698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16122423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16273209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16287976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16314451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16381832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16446010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16483934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16495412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16713585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-16736020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-17043305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17585049-17203459
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1355-8382
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1172-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17585049-3' Untranslated Regions,
pubmed-meshheading:17585049-Animals,
pubmed-meshheading:17585049-Cadherins,
pubmed-meshheading:17585049-Cell Line,
pubmed-meshheading:17585049-Homeodomain Proteins,
pubmed-meshheading:17585049-Mice,
pubmed-meshheading:17585049-MicroRNAs,
pubmed-meshheading:17585049-Promoter Regions, Genetic,
pubmed-meshheading:17585049-RNA Interference,
pubmed-meshheading:17585049-Repressor Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
miR-200b mediates post-transcriptional repression of ZFHX1B.
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pubmed:affiliation |
Biotech Research and Innovation Centre, Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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