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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2007-7-27
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pubmed:abstractText |
MicroRNAs (miRNAs) are a class of noncoding small RNAs that regulate gene expression by base pairing with target mRNAs at the 3'-terminal untranslated regions (3'-UTRs), leading to mRNA cleavage or translational repression. Single-nucleotide polymorphisms (SNPs) located at miRNA-binding sites (miRNA-binding SNPs) are likely to affect the expression of the miRNA target and may contribute to the susceptibility of humans to common diseases. We herein performed a genome-wide analysis of SNPs located in the miRNA-binding sites of the 3'-UTR of various human genes. We found that miRNA-binding SNPs are negatively selected in respect to SNP distribution between the miRNA-binding 'seed' sequence and the entire 3'-UTR sequence. Furthermore, we comprehensively defined the expression of each miRNA-binding SNP in cancers versus normal tissues through mining EST databases. Interestingly, we found that some miRNA-binding SNPs exhibit significant different allele frequencies between the human cancer EST libraries and the dbSNP database. More importantly, using human cancer specimens against the dbSNP database for case-control association studies, we found that twelve miRNA-binding SNPs indeed display an aberrant allele frequency in human cancers. Hence, SNPs located in miRNA-binding sites affect miRNA target expression and function, and are potentially associated with cancers.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-11779458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-12202040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-12434020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-14691535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-14709173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-14744438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-14973191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-14983173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15131085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15172979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15372041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15372042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15502875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15610730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15652477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15685193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15723116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15806104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15852042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-15944708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-16251535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-16258535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-16321941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-16337999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-16381832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-16381944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-16706736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17584784-16736023
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1362-4962
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4535-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17584784-3' Untranslated Regions,
pubmed-meshheading:17584784-Binding Sites,
pubmed-meshheading:17584784-Databases, Nucleic Acid,
pubmed-meshheading:17584784-Gene Expression Regulation,
pubmed-meshheading:17584784-Gene Frequency,
pubmed-meshheading:17584784-Gene Library,
pubmed-meshheading:17584784-Genome, Human,
pubmed-meshheading:17584784-Humans,
pubmed-meshheading:17584784-MicroRNAs,
pubmed-meshheading:17584784-Neoplasms,
pubmed-meshheading:17584784-Polymorphism, Single Nucleotide,
pubmed-meshheading:17584784-RNA, Messenger
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pubmed:year |
2007
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pubmed:articleTitle |
Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers.
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pubmed:affiliation |
Health Sector, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Québec, Canada. zhenbao.yu@nrc.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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