| pubmed-article:17580279 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17580279 | lifeskim:mentions | umls-concept:C0025286 | lld:lifeskim |
| pubmed-article:17580279 | lifeskim:mentions | umls-concept:C0026255 | lld:lifeskim |
| pubmed-article:17580279 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:17580279 | lifeskim:mentions | umls-concept:C0812425 | lld:lifeskim |
| pubmed-article:17580279 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:17580279 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:17580279 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:17580279 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17580279 | pubmed:dateCreated | 2007-6-20 | lld:pubmed |
| pubmed-article:17580279 | pubmed:abstractText | Mitotic activity is one of the most reliable prognostic factors in meningiomas. The identification of mitotic figures (MFs) and the areas of highest mitotic activity in H&E-stained slides is a tedious and subjective task. Therefore, we compared the results from immunostaining for the mitosis-specific antibody anti-phosphohistone H3 (PHH3 mitotic index [MI]) with standard MF counts (H&E MI) and the Ki-67 labeling index (LI). The relationship between these proliferation indices and prognosis was investigated in a retrospective series of 265 meningiomas. The PHH3 staining method yielded greater sensitivity in the detection of MFs and facilitated MF counting. Mitotic thresholds of H&E MI of 4 or more per 10 high-power fields (HPF) and PHH3 MI of 6 or more per 10 HPF were found as the most appropriate prognostic cutoff values for the prediction of recurrence-free survival. All 3 proliferation indices were univariately associated with recurrences and deaths. In contrast with the Ki-67 LI, H&E MI and PHH3 MI also remained as independent predictors in the multivariate Cox hazards modeling (P = .0007 and P = .0004, respectively). | lld:pubmed |
| pubmed-article:17580279 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17580279 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17580279 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17580279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17580279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17580279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17580279 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17580279 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17580279 | pubmed:issn | 0002-9173 | lld:pubmed |
| pubmed-article:17580279 | pubmed:author | pubmed-author:FeidenWolfgan... | lld:pubmed |
| pubmed-article:17580279 | pubmed:author | pubmed-author:KetterRalfR | lld:pubmed |
| pubmed-article:17580279 | pubmed:author | pubmed-author:SteudelWolf-I... | lld:pubmed |
| pubmed-article:17580279 | pubmed:author | pubmed-author:KimYoo-JinYJ | lld:pubmed |
| pubmed-article:17580279 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17580279 | pubmed:volume | 128 | lld:pubmed |
| pubmed-article:17580279 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17580279 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17580279 | pubmed:pagination | 118-25 | lld:pubmed |
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| pubmed-article:17580279 | pubmed:meshHeading | pubmed-meshheading:17580279... | lld:pubmed |
| pubmed-article:17580279 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17580279 | pubmed:articleTitle | Prognostic significance of the mitotic index using the mitosis marker anti-phosphohistone H3 in meningiomas. | lld:pubmed |
| pubmed-article:17580279 | pubmed:affiliation | Institute of Neuropathology, Saarland University, School of Medicine, Homburg/Saar, Germany. | lld:pubmed |
| pubmed-article:17580279 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17580279 | lld:pubmed |
