Source:http://linkedlifedata.com/resource/pubmed/id/17580279
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2007-6-20
|
| pubmed:abstractText |
Mitotic activity is one of the most reliable prognostic factors in meningiomas. The identification of mitotic figures (MFs) and the areas of highest mitotic activity in H&E-stained slides is a tedious and subjective task. Therefore, we compared the results from immunostaining for the mitosis-specific antibody anti-phosphohistone H3 (PHH3 mitotic index [MI]) with standard MF counts (H&E MI) and the Ki-67 labeling index (LI). The relationship between these proliferation indices and prognosis was investigated in a retrospective series of 265 meningiomas. The PHH3 staining method yielded greater sensitivity in the detection of MFs and facilitated MF counting. Mitotic thresholds of H&E MI of 4 or more per 10 high-power fields (HPF) and PHH3 MI of 6 or more per 10 HPF were found as the most appropriate prognostic cutoff values for the prediction of recurrence-free survival. All 3 proliferation indices were univariately associated with recurrences and deaths. In contrast with the Ki-67 LI, H&E MI and PHH3 MI also remained as independent predictors in the multivariate Cox hazards modeling (P = .0007 and P = .0004, respectively).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0002-9173
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
128
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
118-25
|
| pubmed:meshHeading |
pubmed-meshheading:17580279-Adolescent,
pubmed-meshheading:17580279-Adult,
pubmed-meshheading:17580279-Aged,
pubmed-meshheading:17580279-Aged, 80 and over,
pubmed-meshheading:17580279-Biological Markers,
pubmed-meshheading:17580279-Child,
pubmed-meshheading:17580279-Child, Preschool,
pubmed-meshheading:17580279-Cohort Studies,
pubmed-meshheading:17580279-Female,
pubmed-meshheading:17580279-Histones,
pubmed-meshheading:17580279-Humans,
pubmed-meshheading:17580279-Immunohistochemistry,
pubmed-meshheading:17580279-Ki-67 Antigen,
pubmed-meshheading:17580279-Male,
pubmed-meshheading:17580279-Meningeal Neoplasms,
pubmed-meshheading:17580279-Meningioma,
pubmed-meshheading:17580279-Middle Aged,
pubmed-meshheading:17580279-Mitotic Index,
pubmed-meshheading:17580279-Phosphorylation,
pubmed-meshheading:17580279-Prognosis,
pubmed-meshheading:17580279-Retrospective Studies
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Prognostic significance of the mitotic index using the mitosis marker anti-phosphohistone H3 in meningiomas.
|
| pubmed:affiliation |
Institute of Neuropathology, Saarland University, School of Medicine, Homburg/Saar, Germany.
|
| pubmed:publicationType |
Journal Article
|