| pubmed-article:17570691 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17570691 | lifeskim:mentions | umls-concept:C0599752 | lld:lifeskim |
| pubmed-article:17570691 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:17570691 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:17570691 | lifeskim:mentions | umls-concept:C0020835 | lld:lifeskim |
| pubmed-article:17570691 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:17570691 | lifeskim:mentions | umls-concept:C0206071 | lld:lifeskim |
| pubmed-article:17570691 | lifeskim:mentions | umls-concept:C1420815 | lld:lifeskim |
| pubmed-article:17570691 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:17570691 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17570691 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17570691 | pubmed:dateCreated | 2007-6-21 | lld:pubmed |
| pubmed-article:17570691 | pubmed:abstractText | Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of protective immunoglobulin A (IgA) antibodies. The distal intestine contains IgA(2), which is more resistant to bacterial proteases than is IgA(1). The mechanism by which B cells switch from IgM to IgA(2) remains unknown. We found that human intestinal epithelial cells (IECs) triggered IgA(2) class switching in B cells, including IgA(1)-expressing B cells arriving from mucosal follicles, through a CD4(+) T cell-independent pathway involving a proliferation-inducing ligand (APRIL). IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. Our data indicate that bacteria elicit IgA(2) class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL. Thus, mucosal vaccines should activate IECs to induce more effective IgA(2) responses. | lld:pubmed |
| pubmed-article:17570691 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17570691 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17570691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17570691 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17570691 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17570691 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:ChadburnAmyA | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:PlebaniAlessa... | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:RescignoMaria... | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:KnowlesDaniel... | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:HeBingB | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:ChiuAprilA | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:CeruttiAndrea... | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:VillanacciVin... | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:SantiniPaul... | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:XuWeifengW | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:PolydoridesAl... | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:EstrellaJeann... | lld:pubmed |
| pubmed-article:17570691 | pubmed:author | pubmed-author:ShanMeimeiM | lld:pubmed |
| pubmed-article:17570691 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17570691 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17570691 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17570691 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17570691 | pubmed:pagination | 812-26 | lld:pubmed |
| pubmed-article:17570691 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:meshHeading | pubmed-meshheading:17570691... | lld:pubmed |
| pubmed-article:17570691 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17570691 | pubmed:articleTitle | Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. | lld:pubmed |
| pubmed-article:17570691 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA. | lld:pubmed |
| pubmed-article:17570691 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17570691 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17570691 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17570691 | lld:pubmed |
