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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-6-21
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pubmed:abstractText |
Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of protective immunoglobulin A (IgA) antibodies. The distal intestine contains IgA(2), which is more resistant to bacterial proteases than is IgA(1). The mechanism by which B cells switch from IgM to IgA(2) remains unknown. We found that human intestinal epithelial cells (IECs) triggered IgA(2) class switching in B cells, including IgA(1)-expressing B cells arriving from mucosal follicles, through a CD4(+) T cell-independent pathway involving a proliferation-inducing ligand (APRIL). IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. Our data indicate that bacteria elicit IgA(2) class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL. Thus, mucosal vaccines should activate IECs to induce more effective IgA(2) responses.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:CeruttiAndreaA,
pubmed-author:ChadburnAmyA,
pubmed-author:ChiuAprilA,
pubmed-author:EstrellaJeannelynJ,
pubmed-author:HeBingB,
pubmed-author:KnowlesDaniel MDM,
pubmed-author:PlebaniAlessandroA,
pubmed-author:PolydoridesAlexandros DAD,
pubmed-author:RescignoMariaM,
pubmed-author:SantiniPaul APA,
pubmed-author:ShanMeimeiM,
pubmed-author:VillanacciVincenzoV,
pubmed-author:XuWeifengW
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
812-26
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17570691-Antigens, CD40,
pubmed-meshheading:17570691-B-Lymphocytes,
pubmed-meshheading:17570691-Bacteria,
pubmed-meshheading:17570691-Bacterial Vaccines,
pubmed-meshheading:17570691-Base Sequence,
pubmed-meshheading:17570691-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17570691-Cytokines,
pubmed-meshheading:17570691-Dendritic Cells,
pubmed-meshheading:17570691-Humans,
pubmed-meshheading:17570691-Immunoglobulin A,
pubmed-meshheading:17570691-Immunoglobulin Class Switching,
pubmed-meshheading:17570691-Intestinal Mucosa,
pubmed-meshheading:17570691-Intestines,
pubmed-meshheading:17570691-Molecular Sequence Data,
pubmed-meshheading:17570691-Mucous Membrane,
pubmed-meshheading:17570691-Toll-Like Receptors,
pubmed-meshheading:17570691-Tumor Necrosis Factor Ligand Superfamily Member 13
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pubmed:year |
2007
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pubmed:articleTitle |
Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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