Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5831
pubmed:dateCreated
2007-6-15
pubmed:abstractText
The repetitive DNA that constitutes most of the heterochromatic regions of metazoan genomes has hindered the comprehensive analysis of gene content and other functions. We have generated a detailed computational and manual annotation of 24 megabases of heterochromatic sequence in the Release 5 Drosophila melanogaster genome sequence. The heterochromatin contains a minimum of 230 to 254 protein-coding genes, which are conserved in other Drosophilids and more diverged species, as well as 32 pseudogenes and 13 noncoding RNAs. Improved methods revealed that more than 77% of this heterochromatin sequence, including introns and intergenic regions, is composed of fragmented and nested transposable elements and other repeated DNAs. Drosophila heterochromatin contains "islands" of highly conserved genes embedded in these "oceans" of complex repeats, which may require special expression and splicing mechanisms.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-10655227, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-11130711, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-11181995, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-11237011, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-11483983, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-12537571, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-12537573, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-12537574, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-12560500, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-14654010, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-14656963, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-14709175, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-15084738, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-15608223, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-15608241, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-15802507, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-16507169, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-16951679, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-17065610, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-17065611, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-17134480, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-17137733, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-17346786, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-17569867, http://linkedlifedata.com/resource/pubmed/commentcorrection/17569856-9862982
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
316
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1586-91
pubmed:dateRevised
2011-6-7
pubmed:meshHeading
pubmed-meshheading:17569856-Animals, pubmed-meshheading:17569856-Chromosome Mapping, pubmed-meshheading:17569856-Computational Biology, pubmed-meshheading:17569856-Conserved Sequence, pubmed-meshheading:17569856-DNA, Complementary, pubmed-meshheading:17569856-DNA Transposable Elements, pubmed-meshheading:17569856-Drosophila, pubmed-meshheading:17569856-Drosophila Proteins, pubmed-meshheading:17569856-Drosophila melanogaster, pubmed-meshheading:17569856-Exons, pubmed-meshheading:17569856-Expressed Sequence Tags, pubmed-meshheading:17569856-Genes, Insect, pubmed-meshheading:17569856-Genome, pubmed-meshheading:17569856-Heterochromatin, pubmed-meshheading:17569856-Insects, pubmed-meshheading:17569856-Introns, pubmed-meshheading:17569856-Pseudogenes, pubmed-meshheading:17569856-RNA, Untranslated, pubmed-meshheading:17569856-Repetitive Sequences, Nucleic Acid, pubmed-meshheading:17569856-Retroelements, pubmed-meshheading:17569856-Sequence Analysis, DNA
pubmed:year
2007
pubmed:articleTitle
The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
pubmed:affiliation
Department of Biology, San Francisco State University, San Francisco, CA 94132, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural