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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
29
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pubmed:dateCreated |
2007-7-2
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pubmed:abstractText |
CpG oligodeoxynucleotides are potent immunostimulants. In this study, CPG 7909 was formulated with the recombinant Plasmodium falciparum protein AMA1-C1 adsorbed to Alhydrogel (aluminum hydroxide) and used to immunize mice. Mice receiving free CPG 7909 in a separate same site injection to the AMA1-C1/Alhydrogel had the same antibody responses as mice receiving AMA1-C1/Alhydrogel alone. For mice immunized with CPG 7909 bound to the AMA1-C1/Alhydrogel formulation, there was a bell shaped CPG 7909 dose-response curve with the highest antibody response co-incident with the concentration of CPG 7909 that saturated binding to the Alhydrogel. At a higher CPG 7909 dose where 74% was unbound, there was no enhancement of response over AMA1-C1/Alhydrogel alone. Our results suggest that the adjuvant effects of CpGs are optimal when adsorbed to Alhydrogel and highlight the need for careful characterization of the vaccine formulation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-10640783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-10940883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-11130078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-12438374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-14638762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-15233736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-15297066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-15542181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-15622454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-15752840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-15908397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-16135900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-16434128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17566616-7700380
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5343-7
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:17566616-Animals,
pubmed-meshheading:17566616-Antibodies, Protozoan,
pubmed-meshheading:17566616-Antigens, Protozoan,
pubmed-meshheading:17566616-Dose-Response Relationship, Immunologic,
pubmed-meshheading:17566616-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17566616-Female,
pubmed-meshheading:17566616-Immunoglobulin G,
pubmed-meshheading:17566616-Malaria,
pubmed-meshheading:17566616-Malaria Vaccines,
pubmed-meshheading:17566616-Mice,
pubmed-meshheading:17566616-Oligodeoxyribonucleotides,
pubmed-meshheading:17566616-Plasmodium falciparum
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pubmed:year |
2007
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pubmed:articleTitle |
Enhanced antibody production in mice to the malaria antigen AMA1 by CPG 7909 requires physical association of CpG and antigen.
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pubmed:affiliation |
Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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