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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-9-10
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pubmed:abstractText |
Several members of the ATP binding cassette (ABC)-transporter super family expressed in macrophages protect against atherosclerosis by promoting macrophage cholesterol and phospholipid efflux. Systemic disruption of ABCB4 in mice results in a virtual absence of phospholipids in bile and a strongly impaired biliary cholesterol secretion, indicating that ABCB4 plays an essential role in cellular lipid efflux. The aim of the current study was to determine the role of bone marrow-derived ABCB4 in atherosclerotic lesion development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-83
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pubmed:meshHeading |
pubmed-meshheading:17560559-Animals,
pubmed-meshheading:17560559-Aorta,
pubmed-meshheading:17560559-Atherosclerosis,
pubmed-meshheading:17560559-Base Sequence,
pubmed-meshheading:17560559-Bone Marrow,
pubmed-meshheading:17560559-Bone Marrow Transplantation,
pubmed-meshheading:17560559-Cholesterol,
pubmed-meshheading:17560559-DNA Primers,
pubmed-meshheading:17560559-Female,
pubmed-meshheading:17560559-Foam Cells,
pubmed-meshheading:17560559-Lipoproteins,
pubmed-meshheading:17560559-Macrophages, Peritoneal,
pubmed-meshheading:17560559-Mice,
pubmed-meshheading:17560559-Mice, Inbred C57BL,
pubmed-meshheading:17560559-Mice, Knockout,
pubmed-meshheading:17560559-Molecular Sequence Data,
pubmed-meshheading:17560559-P-Glycoproteins,
pubmed-meshheading:17560559-Phospholipids,
pubmed-meshheading:17560559-Receptors, LDL
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pubmed:year |
2007
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pubmed:articleTitle |
Bone marrow-derived multidrug resistance protein ABCB4 protects against atherosclerotic lesion development in LDL receptor knockout mice.
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pubmed:affiliation |
Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands. pennings@lacdr.leidenuniv.nl
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pubmed:publicationType |
Journal Article
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