| pubmed-article:17553869 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C0206679 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C0012939 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C0699919 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C1428059 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C0439659 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:17553869 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:17553869 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:17553869 | pubmed:dateCreated | 2007-8-16 | lld:pubmed |
| pubmed-article:17553869 | pubmed:abstractText | Although the seven viral proteins required for herpes simplex virus type 1 (HSV-1) DNA replication have been identified, the mechanism by which viral DNA synthesis is regulated is unclear. HSV-1 DNA replication is thought to occur in two stages: origin-dependent DNA replication (stage I) mediated by the origin binding protein (OBP), followed by origin- and OBP-independent DNA replication (stage II). The mechanism that facilitates the switch from stage I to stage II is unknown; however, it must involve the loss of OBP function or OBP itself from the replication initiation complex. Previous studies from this laboratory identified a transcript (UL8.5) and protein (OBPC) that are in frame with and comprise the C terminus of the gene specifying OBP. Because of its DNA binding ability, OBPC has been hypothesized to mediate the switch from stage I to stage II. Here, we identify a second protein (OBPC-2) that is also in frame with the C terminus of OBP but comprises a smaller portion of the protein. We demonstrate that the protein originally identified (OBPC-1) is a cathepsin B-mediated cleavage product of OBP, while OBPC-2 may be the product of the UL8.5 transcript. We further demonstrate that the cleavage of OBP to yield OBPC-1 is dependent upon viral DNA replication. These results suggest that cleavage may be a mechanism by which OBP levels and/or activity are regulated during infection. | lld:pubmed |
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| pubmed-article:17553869 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17553869 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17553869 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17553869 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17553869 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17553869 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:17553869 | pubmed:author | pubmed-author:SchafferPrisc... | lld:pubmed |
| pubmed-article:17553869 | pubmed:author | pubmed-author:LinkMalen AMA | lld:pubmed |
| pubmed-article:17553869 | pubmed:author | pubmed-author:SilvaLaurie... | lld:pubmed |
| pubmed-article:17553869 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17553869 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:17553869 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17553869 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17553869 | pubmed:pagination | 9175-82 | lld:pubmed |
