Source:http://linkedlifedata.com/resource/umls/id/C0699919
MSH: A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.,NCI: Cathepsin B, encoded by the CTSB Gene, encodes a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of Cathepsin B has been associated with esophageal adenocarcinoma and other tumors. Tumors with overexpression of cathepsins have powerful potential for invasiveness in the early stage of gastric carcinom