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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-7-30
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pubmed:abstractText |
Xenobiotic-metabolizing enzymes are widely polymorphic and confer interindividual variation in the ability to detoxify carcinogens or to activate pro-carcinogens. A common polymorphism of cytochrome P450 2D6 (CYP2D6) results in lack of enzyme activity and has been associated with an altered susceptibility to several cancers. The aim of this study was to investigate the association between the CYP2D6 poor metaboliser genotype and the risk of papillary thyroid cancer (PTC).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0300-0664
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
180-3
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pubmed:meshHeading |
pubmed-meshheading:17547692-Adenocarcinoma, Papillary,
pubmed-meshheading:17547692-Adult,
pubmed-meshheading:17547692-Case-Control Studies,
pubmed-meshheading:17547692-Chi-Square Distribution,
pubmed-meshheading:17547692-Cytochrome P-450 CYP2D6,
pubmed-meshheading:17547692-Female,
pubmed-meshheading:17547692-Gene Frequency,
pubmed-meshheading:17547692-Genetic Predisposition to Disease,
pubmed-meshheading:17547692-Heterozygote,
pubmed-meshheading:17547692-Homozygote,
pubmed-meshheading:17547692-Humans,
pubmed-meshheading:17547692-Male,
pubmed-meshheading:17547692-Middle Aged,
pubmed-meshheading:17547692-Polymorphism, Genetic,
pubmed-meshheading:17547692-Retrospective Studies,
pubmed-meshheading:17547692-Thyroid Neoplasms
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pubmed:year |
2007
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pubmed:articleTitle |
Genetic polymorphism of CYP2D6 influences susceptibility to papillary thyroid cancer.
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pubmed:affiliation |
Centro de Investigação em Ciências da Saúde (CICS), Faculdade de Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal. mclemos@fcsaude.ubi.pt
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pubmed:publicationType |
Journal Article
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