Linked Life Data

17540578

Source:http://linkedlifedata.com/resource/pubmed/id/17540578

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pubmed-article:17540578pubmed:abstractTextThe aim of this study was to examine whether tumor necrosis factor (TNF)-alpha expression in the phagocytic activity of RAW macrophages by trans10-cis12 (10t-12c) conjugated linoleic acid (CLA) is associated with peroxisome proliferator-activated receptor gamma (PPARgamma) activation. 10t-12c CLA induced the TNF-alpha expression in RAW macrophages. Phagocytic activity of naive RAW macrophages was increased either by recombinant mouse (rm) TNF-alpha or by culture supernatant from 10t-12c CLA-treated RAW macrophages. This phagocytic activity was inhibited by addition of anti-rmTNF-alpha polyclonal antibody (pAb). 10t-12c CLA also increased the level of PPARgamma protein and mRNA in RAW macrophages. When naive RAW macrophages were incubated with the culture supernatant from RAW macrophages treated with 10t-12c CLA plus GW 9662, a PPARgamma antagonist, their phagocytic activity was significantly inhibited. In addition, GW 9662 antagonized the effect of 10t-12c CLA in stimulating TNF-alpha expression. These results suggest that 10t-12c CLA modulates the phagocytic activity of RAW macrophages by upregulating TNF-alpha expression via a PPARgamma-dependent pathway.lld:pubmed
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pubmed-article:17540578pubmed:authorpubmed-author:JeungEui-BaeE...lld:pubmed
pubmed-article:17540578pubmed:authorpubmed-author:LeeGeun-ShikG...lld:pubmed
pubmed-article:17540578pubmed:authorpubmed-author:YangMhan-PyoM...lld:pubmed
pubmed-article:17540578pubmed:authorpubmed-author:KangJi-HounJHlld:pubmed
pubmed-article:17540578pubmed:authorpubmed-author:SongDeok-HoDHlld:pubmed
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pubmed-article:17540578pubmed:volume37lld:pubmed
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pubmed-article:17540578pubmed:year2007lld:pubmed
pubmed-article:17540578pubmed:articleTitleUpregulation of tumor necrosis factor-alpha expression by trans10-cis12 conjugated linoleic acid enhances phagocytosis of RAW macrophages via a peroxisome proliferator-activated receptor gamma-dependent pathway.lld:pubmed
pubmed-article:17540578pubmed:affiliationLaboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.lld:pubmed
pubmed-article:17540578pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17540578pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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