Linked Life Data

17532652

Source:http://linkedlifedata.com/resource/pubmed/id/17532652

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-8-6
pubmed:abstractText
Extra copies of chromosome 21 are often found in sporadic leukemias. Constitutional trisomy 21 of Down syndrome (DS) is associated with markedly increased risk for childhood leukemia. Thus the oncogenic role of trisomy 21 in the more common sporadic childhood leukemias may be revealed through the investigations of the relatively rare leukemias of DS. Recent studies of the megakaryoblastic leukemias of Down syndrome have uncovered a developmental leukemogenic mechanism characterized by a unique pre-natal collaboration between overexpressed genes from chromosome 21 and an acquired mutation in the transcription factor GATA1. The base of the markedly enhanced risk for acute lymphoblastic leukemia conferred by trisomy 21 is still unclear. Studies of the leukemias of DS are likely to contribute to the general understanding of the oncogenic mechanisms of chromosomal aneuploidies, the most common abnormalities in cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1079-9796
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
156-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Trisomy of chromosome 21 in leukemogenesis.
pubmed:affiliation
Research Section of Childhood Malignancies, Department of Pediatric Hemato-Oncology, and the Sheba Cancer Research Center, Sheba Medical Hospital, Tel-Hashomer, Ramat-Gan 52621, Israel. sizraeli@sheba.health.gov.il
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't