|
rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
9
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pubmed:dateCreated |
2007-5-28
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|
pubmed:abstractText |
In most colorectal carcinomas, the level of phospholipase C (PLC)-gamma 1 expression is greatly elevated. Increased expression of PLC-gamma 1 may play an important role in colon carcinogenesis, but the mechanism is not well known. The aim of this study was to evaluate the role of PLC-gamma 1 in colon carcinogenesis by using recombinant lentivirus that stably suppressed the PLC-gamma 1 expression in human colorectal carcinoma LoVo cells.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0366-6999
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
5
|
|
pubmed:volume |
120
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
749-54
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|
pubmed:meshHeading |
pubmed-meshheading:17531112-Apoptosis,
pubmed-meshheading:17531112-Cell Adhesion,
pubmed-meshheading:17531112-Cell Line, Tumor,
pubmed-meshheading:17531112-Colorectal Neoplasms,
pubmed-meshheading:17531112-Fluorouracil,
pubmed-meshheading:17531112-Humans,
pubmed-meshheading:17531112-Laminin,
pubmed-meshheading:17531112-Lentivirus,
pubmed-meshheading:17531112-Phospholipase C gamma,
pubmed-meshheading:17531112-RNA, Small Interfering
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA.
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|
pubmed:affiliation |
Department of Cell Biology, Southern Medical University, and Zhujiang Hospital, Guangzhou 510515, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
