Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-5-25
pubmed:abstractText
A history of an escalating chronic intractable pain in a patient with cryoglobulinemia, vasculitis, and severe cutaneous ulcerations is presented. A strategy of progressive, multi-agent, N-methyl-D-aspartate-receptor (NMDA-R) blockade that resulted in adequate pain control and a three-fold reduction in opioid consumption is described. Diagnostic process of neuropathic pain and the role of NMDA-R in the development of hyperalgesia are briefly reviewed. Thereafter, existing clinical literature describing the use of Ketamine, a major NMDA-R antagonist for management of malignant pain, is reviewed. Lastly, evidence-based original protocol for intravenous adjuvant Ketamine analgesia for severe cancer pain is presented.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amines, http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid, http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanecarboxylic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Ketamine, http://linkedlifedata.com/resource/pubmed/chemical/Methadone, http://linkedlifedata.com/resource/pubmed/chemical/Methylphenidate, http://linkedlifedata.com/resource/pubmed/chemical/Oxycodone, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate, http://linkedlifedata.com/resource/pubmed/chemical/gabapentin, http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1533-3159
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
493-500
pubmed:meshHeading
pubmed-meshheading:17525784-Adult, pubmed-meshheading:17525784-Amines, pubmed-meshheading:17525784-Analgesics, pubmed-meshheading:17525784-Analgesics, Opioid, pubmed-meshheading:17525784-Central Nervous System, pubmed-meshheading:17525784-Cryoglobulinemia, pubmed-meshheading:17525784-Cyclohexanecarboxylic Acids, pubmed-meshheading:17525784-Drug Therapy, Combination, pubmed-meshheading:17525784-Excitatory Amino Acid Antagonists, pubmed-meshheading:17525784-Female, pubmed-meshheading:17525784-Hepatitis C, pubmed-meshheading:17525784-Humans, pubmed-meshheading:17525784-Ketamine, pubmed-meshheading:17525784-Methadone, pubmed-meshheading:17525784-Methylphenidate, pubmed-meshheading:17525784-Oxycodone, pubmed-meshheading:17525784-Pain, Intractable, pubmed-meshheading:17525784-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:17525784-Treatment Outcome, pubmed-meshheading:17525784-Ulcer, pubmed-meshheading:17525784-Vasculitis, pubmed-meshheading:17525784-gamma-Aminobutyric Acid
pubmed:year
2007
pubmed:articleTitle
Ketamine: an introduction for the pain and palliative medicine physician.
pubmed:affiliation
Department of Palliative Medicine, Marshfield Clinic, Marshfield, WI 54449, USA. okon.tomasz@marshfieldclinic.org
pubmed:publicationType
Journal Article, Review, Case Reports