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rdf:type |
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lifeskim:mentions |
umls-concept:C0152171,
umls-concept:C0205314,
umls-concept:C0289417,
umls-concept:C0332307,
umls-concept:C0597357,
umls-concept:C0679622,
umls-concept:C0682323,
umls-concept:C0851285,
umls-concept:C1658578,
umls-concept:C1704675,
umls-concept:C1879547
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pubmed:issue |
23
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pubmed:dateCreated |
2007-6-12
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pubmed:abstractText |
Pulmonary arterial hypertension (PAH) is characterized by selective elevation of pulmonary arterial pressure. The pathological hallmark of PAH is the narrowing of pulmonary arterioles secondary to endothelial cell dysfunction and smooth muscle cell proliferation. Heterozygous mutations in BMPR2, encoding the type II bone morphogenetic protein receptor (BMPRII), were identified in PAH, suggesting that alterations to BMPRII function are involved in disease onset and/or progression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:EickelbergOliverO,
pubmed-author:HeckerMatthiasM,
pubmed-author:KwapiszewskaGrazynaG,
pubmed-author:MORRWW,
pubmed-author:MarshLeigh MLM,
pubmed-author:MorrellNicholas WNW,
pubmed-author:MortyRory ERE,
pubmed-author:NejmanBozenaB,
pubmed-author:SchermulyRalph TRT,
pubmed-author:SeegerWernerW,
pubmed-author:ZakrzewiczAnnaA
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2957-68
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17515463-Adult,
pubmed-meshheading:17515463-Animals,
pubmed-meshheading:17515463-Bone Morphogenetic Protein Receptors, Type II,
pubmed-meshheading:17515463-Cell Proliferation,
pubmed-meshheading:17515463-Down-Regulation,
pubmed-meshheading:17515463-Female,
pubmed-meshheading:17515463-GTP-Binding Proteins,
pubmed-meshheading:17515463-Humans,
pubmed-meshheading:17515463-Hypertension, Pulmonary,
pubmed-meshheading:17515463-Male,
pubmed-meshheading:17515463-Mice,
pubmed-meshheading:17515463-Middle Aged,
pubmed-meshheading:17515463-Muscle, Smooth, Vascular,
pubmed-meshheading:17515463-Mutation,
pubmed-meshheading:17515463-Myocytes, Smooth Muscle,
pubmed-meshheading:17515463-Neoplasm Proteins,
pubmed-meshheading:17515463-Protein Binding,
pubmed-meshheading:17515463-Rats,
pubmed-meshheading:17515463-Receptors, Cell Surface,
pubmed-meshheading:17515463-Smad1 Protein,
pubmed-meshheading:17515463-Two-Hybrid System Techniques
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pubmed:year |
2007
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pubmed:articleTitle |
Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension.
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pubmed:affiliation |
University of Giessen Lung Center, Department of Medicine II, Justus Liebig University Giessen, D-35392 Giessen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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