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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-8-29
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pubmed:abstractText |
A major goal in genetic studies of type 1A diabetes is prediction of anti-islet autoimmunity and subsequent diabetes in the general population, as >85% of patients do not have a first-degree relative with type 1A diabetes. Given prior association studies, we hypothesized that the strongest candidates for enhancing diabetes risk among DR3-DQB1*0201/DR4-DQB1*0302 individuals would be alleles of DP and DRB1*04 subtypes and, in particular, the absence of reportedly protective alleles DPB1*0402 and/or DRB1*0403.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:AlyTheresa ATA,
pubmed-author:BabuSunanda RSR,
pubmed-author:BarrigaKatherine JKJ,
pubmed-author:BaschalErin EEE,
pubmed-author:EisenbarthGeorge SGS,
pubmed-author:ErlichHenry AHA,
pubmed-author:FernandoMaria SMS,
pubmed-author:MiaoDongmeiD,
pubmed-author:NobleJanelle AJA,
pubmed-author:NorrisJill MJM,
pubmed-author:RewersMarian JMJ,
pubmed-author:YuLipingL
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pubmed:issnType |
Electronic
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2405-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17513705-Child,
pubmed-meshheading:17513705-Diabetes Mellitus, Type 1,
pubmed-meshheading:17513705-Genotype,
pubmed-meshheading:17513705-HLA-D Antigens,
pubmed-meshheading:17513705-HLA-DP Antigens,
pubmed-meshheading:17513705-HLA-DP beta-Chains,
pubmed-meshheading:17513705-HLA-DQ Antigens,
pubmed-meshheading:17513705-HLA-DQ beta-Chains,
pubmed-meshheading:17513705-Histocompatibility Testing,
pubmed-meshheading:17513705-Humans,
pubmed-meshheading:17513705-Nuclear Family,
pubmed-meshheading:17513705-Risk Assessment,
pubmed-meshheading:17513705-Survival
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pubmed:year |
2007
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pubmed:articleTitle |
HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population.
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pubmed:affiliation |
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045-6511, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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