rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0033325,
umls-concept:C0185117,
umls-concept:C0205177,
umls-concept:C0205263,
umls-concept:C0242184,
umls-concept:C0476089,
umls-concept:C1412812,
umls-concept:C1521761,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2911684
|
pubmed:issue |
2
|
pubmed:dateCreated |
2008-1-28
|
pubmed:abstractText |
BNIP3 is a pro-apoptotic mitochondrial protein induced under hypoxic stress, with the BNIP3 gene being under direct regulation of the hypoxia-inducible HIF-1alpha transcription factor. Induction of BNIP3 leads to caspase-independent necrosis-like cell death and an aggressive tumour phenotype. The role of BNIP3 in endometrial cancer was examined.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1472-4146
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
61
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
217-20
|
pubmed:meshHeading |
pubmed-meshheading:17513511-Adenocarcinoma,
pubmed-meshheading:17513511-Cytoplasm,
pubmed-meshheading:17513511-Endometrial Neoplasms,
pubmed-meshheading:17513511-Female,
pubmed-meshheading:17513511-Humans,
pubmed-meshheading:17513511-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:17513511-Membrane Proteins,
pubmed-meshheading:17513511-Neoplasm Invasiveness,
pubmed-meshheading:17513511-Neoplasm Proteins,
pubmed-meshheading:17513511-Prognosis,
pubmed-meshheading:17513511-Proto-Oncogene Proteins,
pubmed-meshheading:17513511-Signal Transduction,
pubmed-meshheading:17513511-Survival Analysis,
pubmed-meshheading:17513511-Tumor Markers, Biological
|
pubmed:year |
2008
|
pubmed:articleTitle |
BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis.
|
pubmed:affiliation |
Department of Pathology, Democritus University of Thrace, Alexandroupolis 68100, Greece. targ@her.forthnet.gr
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|