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rdf:type |
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lifeskim:mentions |
umls-concept:C0017890,
umls-concept:C0026809,
umls-concept:C0086045,
umls-concept:C0175677,
umls-concept:C0205349,
umls-concept:C0439851,
umls-concept:C0441655,
umls-concept:C0475224,
umls-concept:C0521119,
umls-concept:C0596311,
umls-concept:C1330957,
umls-concept:C1552596,
umls-concept:C1707520,
umls-concept:C1947931
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pubmed:issue |
7
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pubmed:dateCreated |
2007-6-26
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pubmed:abstractText |
Ischemia elicits the rapid release of various amino acid neurotransmitters. A glutamate surge activates N-methyl-d-aspartate (NMDA) glutamate receptors, triggering deleterious processes in neurons. Although glycine is a coagonist of the NMDA receptor, the effect of extracellular glycine concentration on ischemic injury remains controversial. To approach this issue, we examined ischemic injury in mice with genetically altered activities of the glycine cleavage multienzyme system (GCS), which plays a fundamental role in maintaining extracellular glycine concentration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine Dehydrogenase...,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/SM 31900,
http://linkedlifedata.com/resource/pubmed/chemical/Taurine,
http://linkedlifedata.com/resource/pubmed/chemical/Transferases,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/glycine cleavage system
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4628
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pubmed:author |
pubmed-author:AokiYokoY,
pubmed-author:FassS JSJ,
pubmed-author:KinouchiHiroyukiH,
pubmed-author:KojimaKanakoK,
pubmed-author:KureShigeoS,
pubmed-author:MatsubaraYoichiY,
pubmed-author:NarisawaAyumiA,
pubmed-author:OdaMasayaM,
pubmed-author:OmaeTomoyaT,
pubmed-author:SatoKenichiK,
pubmed-author:ShinkaToshikatsuT,
pubmed-author:SugawaraTakuT,
pubmed-author:YamaguchiSuguruS
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2157-64
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pubmed:meshHeading |
pubmed-meshheading:17510459-Alanine,
pubmed-meshheading:17510459-Amino Acid Oxidoreductases,
pubmed-meshheading:17510459-Animals,
pubmed-meshheading:17510459-Brain Ischemia,
pubmed-meshheading:17510459-COS Cells,
pubmed-meshheading:17510459-Carrier Proteins,
pubmed-meshheading:17510459-Cercopithecus aethiops,
pubmed-meshheading:17510459-Cerebrovascular Circulation,
pubmed-meshheading:17510459-Glutamic Acid,
pubmed-meshheading:17510459-Glycine,
pubmed-meshheading:17510459-Glycine Dehydrogenase (Decarboxylating),
pubmed-meshheading:17510459-Humans,
pubmed-meshheading:17510459-Indoles,
pubmed-meshheading:17510459-Male,
pubmed-meshheading:17510459-Mice,
pubmed-meshheading:17510459-Mice, Inbred C57BL,
pubmed-meshheading:17510459-Mice, Transgenic,
pubmed-meshheading:17510459-Microdialysis,
pubmed-meshheading:17510459-Multienzyme Complexes,
pubmed-meshheading:17510459-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:17510459-Regional Blood Flow,
pubmed-meshheading:17510459-Taurine,
pubmed-meshheading:17510459-Transferases,
pubmed-meshheading:17510459-gamma-Aminobutyric Acid
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pubmed:year |
2007
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pubmed:articleTitle |
Direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multienzyme system.
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pubmed:affiliation |
Department of Medical Genetics, Tohoku University School of Medicine, Seiryomachi, Aobaku, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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